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Journal of Pharmacology and Toxicology

Year: 2023 | Volume: 18 | Issue: 3 | Page No.: 112-119
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Authors

Ana Maria S. Assreuy

Ana Maria S. Assreuy

Iasly C. Lima

Laryssa F. Mendonca

Livia de P. Pereira

Stephanie L.M.K. Oliveira

Ana Paula N.N. Alves

Maria G. Pereira

Mario Rogerio L. Mota

Keywords

Background and Objective: Diabetes decreases glucose metabolism, leading to hyperglycemia and delayed wound healing. Caesalpinia ferrea or Libidibia ferrea (Fabaceae), popularly known as “pau ferro”, “jucá” or “jucaína”, is widely used in folk medicine for inflammatory conditions. Caesalpinia ferrea barks are used in the form of tea and portions to clean injuries and treat wounds and its stem barks infusion to treat enterocolitis, asthma, bruises, chronic cough and wounds. This study aimed to investigate the effect of the polysaccharide-rich extract of C. ferrea stem barks (PE-Cf) in the model of excisional cutaneous wounds in diabetic rats. Materials and Methods: The PE-Cf was obtained by a combination of NaOH extraction and ethanol precipitation. The analysis of the NMR spectra of PE-Cf revealed a central core composed mostly of 5-linked α-Araf and minority constituents such as α-Rhap and α-GalAp. For diabetes induction, rats received alloxan (45 mg kg–1) by the intravenous route for pancreatic β cell destruction. One month later, rats that had blood glucose >200 mg dL–1 were selected to be tested in the model of the excisional cutaneous wound. PE-Cf (0.025-0.1%) was topically applied to the wounds twice a day for 14 days for evaluation of hyper-nociception (digital analgesimetry), clinical signs (macroscopy) and histopathology/ histomorphometry. Results: 0.1% PE-Cf reduced wound area (2-7th day), hyper-nociception (5-10th day), crust detachment (5-7th day), scar tissue formation (10th day), leukocyte infiltration (5-7th day) and increased fibroblast/myofibroblast (5th and 7th day). Conclusion: The PE-Cf accelerates the healing process of diabetic rats, acting both in the inflammatory and proliferative phases. This study validates the popular use of C. ferrea barks in the inflammatory process and suggests PE-Cf as an alternative therapy to healing diabetic wounds.
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How to cite this article

Ana Maria S. Assreuy, Iasly C. Lima, Laryssa F. Mendonca, Livia de P. Pereira, Stephanie L.M.K. Oliveira, Ana Paula N.N. Alves, Maria G. Pereira and Mario Rogerio L. Mota, 2023. Polysaccharide-Rich Extract of Caesalpinia ferrea Stem Barks Modulates Inflammatory and Proliferative Phases Enhancing Diabetic Cutaneous Wound. Journal of Pharmacology and Toxicology, 18: 112-119.

DOI: 10.3923/jpt.2023.112.119

URL: https://scialert.net/abstract/?doi=jpt.2023.112.119

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