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Journal of Pharmacology and Toxicology
  Year: 2022 | Volume: 17 | Issue: 1 | Page No.: 36-42
DOI: 10.3923/jpt.2022.36.42
 
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Neuroprotective Effects of Virgin Coconut Oil Solubilized Curcumin in Diabetic Peripheral Neuropathy

Nalini More, Varun Joshi, Manoj Mahajan, Chandrashekhar Upasani and Aman Upaganlawar

Abstract:
Background and Objective: Neuropathic pain or peripheral neuropathy is one of the important secondary complications of diabetes. Preventing the severity of pain is one of the challenges and treatment with supporting therapy may extend the complications as well as the pain threshold. Based on the above objective the present study was designed to evaluate the effect of virgin coconut oil solubilized curcumin (VCOSC) on streptozotocin-induced diabetic neuropathy in rats. Materials and Methods: Male albino rats (200-250 g) were used in the entire study. Diabetic peripheral neuropathy (DPN) was induced by the administration of streptozotocin (60 mg/kg, i.p.). The DPN was assessed by evaluating behavioural parameters including mechanical allodynia using Von Frey hair test, cold allodynia using acetone, heat or thermal allodynia using a hot plate, mechanical hyperalgesia using Randall Selitto test and biochemical parameters embracing blood glucose level, endogenous antioxidants such as reduced glutathione, lipid peroxidase, superoxide dismutase and catalase. After 4 weeks of development of DPN, the treatment was started with VCOSC at two different doses (0.66 mg/4 mL/kg) and (1.32 mg/8 mL/kg). Results: VCOSC significantly reduced the serum glucose level and considerably increased body weight in treated animals as compared to disease (DPN) animals. The treatment also showed a remarkable change in the paw withdrawal latency in all the methods of evaluation as compared to diseased rats. A high dose of VCOSC was proved to be more effective in the assessment of paw withdrawal latency in mechanical allodynia, cold allodynia, thermal allodynia and mechanical hyperalgesia. The levels of endogenous antioxidants such as reduced glutathione, catalase, superoxide dismutase and lipid peroxidation were significantly improved as compared to diseased rats. Conclusion: Streptozotocin (STZ) induced rats shows DPN by altering various behavioural and biochemical parameters. The beneficial protective effects of both the compounds might be due to the strong antioxidant activity.
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How to cite this article:

Nalini More, Varun Joshi, Manoj Mahajan, Chandrashekhar Upasani and Aman Upaganlawar, 2022. Neuroprotective Effects of Virgin Coconut Oil Solubilized Curcumin in Diabetic Peripheral Neuropathy. Journal of Pharmacology and Toxicology, 17: 36-42.

DOI: 10.3923/jpt.2022.36.42

URL: https://scialert.net/abstract/?doi=jpt.2022.36.42

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