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Journal of Pharmacology and Toxicology
  Year: 2020 | Volume: 15 | Issue: 2 | Page No.: 44-57
DOI: 10.3923/jpt.2020.44.57
 
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Neuromodulatory Influences of Nutraceuticals on D-galactose Induced Hippocampal Neuronal Metabolic Dysfunction Model
Marwa A. Masoud, Omar A. Ahmed-Farid and Hanan A. Rizk

Abstract:
Background and Objective: D-galactose induced neurotoxicity is widely known model for survey aging and related oxidative neurotoxicity and memory impairment. The present study was conducted to explore the possible role of Linseed Oil (LO) and Coenzyme Q10 (CoQ10) as compared with standard neuroprophylactic Ginkgo biloba extract to protect hippocampal cells against toxic effects induced by D-galactose (D-gal). Materials and Methods: The rats (50 males) were divided randomly into five groups, 10 rats for each, the 1st normal control, the 2nd served as aging treated with D-gal, the 3rd treated with Ginkgo biloba plus D-gal, the 4th group treated with linseed oil plus D-gal, the 5th group treated with Coenzyme Q10 plus D-gal. The experiment lasted for 6 weeks then behavioral tests were examined and then all animals were decapitated for biochemical, neurochemicals, histopathology and immunohistochemistry analysis. Results: Administration of D-gal for 6 weeks significantly impaired behavioral test, oxidative defense, decreased endogenous antioxidant, impaired neurotransmitters contents, increased acetylcholinesterase, inhibited neurogenesis, increased 8-hydroxy-2-deoxyguanosine, decreased ATP and increased apoptotic factors as compared to normal group. Six weeks of linseed oil and coenzyme Q10 treatments significantly improved neurobehavioral alterations, brain derived neurotrophic factor and apoptosis as compared to D-gal. Conclusion: The present study concluded that dietary intake rich with D-gal disrupt neuronal cell structure in accordance with aging which accumulate most neuronal aberration and treating with natural substances may be beneficial in normal aging troubles. In addition, CoQ10 showed best protective effect after 6 weeks of treatment compared with LO and GB which normalized most selected paramours.
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How to cite this article:

Marwa A. Masoud, Omar A. Ahmed-Farid and Hanan A. Rizk, 2020. Neuromodulatory Influences of Nutraceuticals on D-galactose Induced Hippocampal Neuronal Metabolic Dysfunction Model. Journal of Pharmacology and Toxicology, 15: 44-57.

DOI: 10.3923/jpt.2020.44.57

URL: https://scialert.net/abstract/?doi=jpt.2020.44.57

 
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