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Journal of Pharmacology and Toxicology
  Year: 2020 | Volume: 15 | Issue: 1 | Page No.: 1-7
DOI: 10.3923/jpt.2020.1.7
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Effects of Ethanolic Leaf and Stem-bark Extracts of Adansonia digitata in Alloxan-induced Diabetic Wistar Rats

Ojochenemi Ejeh Yakubu , Chinedu Imo , Christopher Shaibu, John Akighir and Daniel Simon Ameh

Background and Objectives: Diabetes mellitus has been a great worry to humanity and the scientific community and researchers have made it a point of challenge and responsibility to bring an end to the quantum of havocs posed by this monster. This study was carried out to evaluate the effects of ethanolic leaf extract and stem-back extract of Adansonia digitata (AD) on liver function, haematology and blood glucose level in alloxan-induced diabetic Wistar rats. Materials and Methods: Twenty-five Wistar rats were distributed into 5 groups of 5 animals each. The test animals were administered alloxan (150 mg kg1) intraperitoneally and were monitored for 72 h for the development of hyperglycemia. Group 1 served as normal control, group 2 served as diabetic control, while groups 3and 4 were diabetic rats treated orally with ethanolic leaf and stem-bark extracts of Adansonia digitata (100 mg kg1), respectively for 21days. Group 5 animals were diabetic rats treated with anti-diabetic drug (glibenclamide). Results: The result of this study indicated a reduced blood glucose level and a significantly (p<0.05) reduced liver function parameters evaluated in the alloxan-induced diabetic treated rats compared with the diabetic control rats. However, there was no specific pattern of increase/decrease in the haematological parameters. Conclusion: This study showed that alloxan-induced diabetes mellitus caused a possible liver disease condition and alteration of the haematological indices. However, administration of the AD leaves extract and AD stem-bark extract exhibited the ability of treating the inflammation and alterations caused by alloxan-induced diabetes.
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  •    Antioxidant Activity of Partially Purified Fractions of Daniellia oliveri (Rolfe) Hutch and Dalziellii Stem Bark Ethanolic Extract
  •    Antidiabetic and Hypolipidemic Potential of 3, 4-dihydroisoquinolin-2(1H)- Sulfonamide in Alloxan Induced Diabetic Rats
  •    Every-Other-Furrow Irrigation with Different Irrigation Intervals for Grain Sorghum
  •    Antioxidant Parameters and GC-MS Phytochemical Analysis of Hymenocardia acida Stem Bark Ethanolic Extract
How to cite this article:

Ojochenemi Ejeh Yakubu, Chinedu Imo, Christopher Shaibu, John Akighir and Daniel Simon Ameh, 2020. Effects of Ethanolic Leaf and Stem-bark Extracts of Adansonia digitata in Alloxan-induced Diabetic Wistar Rats. Journal of Pharmacology and Toxicology, 15: 1-7.

DOI: 10.3923/jpt.2020.1.7






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