Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
Journal of Pharmacology and Toxicology
  Year: 2018 | Volume: 13 | Issue: 1 | Page No.: 45-51
DOI: 10.3923/jpt.2018.45.51
Ulcerogenic Potential of Eucalyptus globulus L. Leaf Extract in Wistar Albino Rats
S.B. Obakiro , L. Bunalema, J. Gakunga-Ndukui, E. Nyatia and J.P. Waako

Abstract:
Background and Objective: Eucalyptus globulus (Myrtaceae) is one of the plants widely used by many traditional medicine practitioners (TMP) in Uganda and the rest of the world. Although efficacy data to support the medicinal use of this plant and its oil is widely documented, there was limited knowledge about its safety profile. This study was therefore conducted to evaluate the effect of the methanolic leaf of E. globulus on biochemical, heamatological and histological indices of the rats after 42 days of single daily oral dose. Materials and Methods: A methanolic leaf extract of Eucalyptus globulus was prepared and its sub-acute toxicity evaluated in Wistar albino rats. Healthy animals were administered with determined doses of the extract daily for up to 42 days. At the end of the study period, blood was collected and analyzed for biochemical and heamatological parameters while tissues from selected vital organs were microscopically examined for histopathological lesions. Numerical data was analyzed using ANOVA and mean statistical differences tested using Dunnett’s test at 95% confidence. Results: The methanolic leaf extract of E. globulus significantly increased the level of neutrophils and lymphocytes but decreased the basophils. It also caused severe sloughing of the intestinal mucosa. Conclusion: It was concluded from current findings that the methanolic leaf extract of E. globulus can cause gastrointestinal ulcers in Wistar rats after subacute administration.
 [Fulltext PDF]   [Fulltext HTML]   [XML: Abstract + References]   [References]   [View Citation]  [Report Citation]
How to cite this article:

S.B. Obakiro, L. Bunalema, J. Gakunga-Ndukui, E. Nyatia and J.P. Waako, 2018. Ulcerogenic Potential of Eucalyptus globulus L. Leaf Extract in Wistar Albino Rats. Journal of Pharmacology and Toxicology, 13: 45-51.

DOI: 10.3923/jpt.2018.45.51

URL: https://scialert.net/abstract/?doi=jpt.2018.45.51

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 

Curve Bottom