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Journal of Pharmacology and Toxicology
  Year: 2018 | Volume: 13 | Issue: 1 | Page No.: 27-36
DOI: 10.3923/jpt.2018.27.36
 
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Determination of Some Phyto-constituents Present in Terminalia catappa Endocarp Flour and Biochemical Evaluation of its Ethanolic Extract on Hepatic Indices in Male Wistar Rats
Anuforo Philemon Chinemezu , Achi Ngozi K, Egbuonu Anthony C. Cemaluk and Egu Elizabeth Uchechi

Abstract:
Objective: This study assessed the determination of phyto-constituents present in Terminalia catappa endocarp (considered a waste) and biochemical evaluation of its ethanol extract on hepatic indices in male wistar rats using monosodium glutamate (MSG) to induce toxicity. Materials and Methods: Twenty four male wistar rats with mean weight of 120.61±15.15 g were divided into six groups (n = 4). Group 1, the normal control group (received distilled water), group II, the negative control (received 8 mg MSG/kg b.wt.), group III, the extract control (received 300 mg kg–1 b.wt., extract), group IV received 8 mg MSG/g b.wt.+100 mg extract/kg b.wt., group V received 8 mg MSG/g b.wt.+300 mg extract/kg b.wt. and group VI received 8 mg MSG/g b.wt.+500 mg extract/kg b.wt. daily by oral gavage for 14 days. Data were subjected to one-way ANOVA followed by Duncan post-hoc test at p<0.05. Results: Phytochemicals studies revealed the presence of flavonoids, saponins, alkaloids, steroids and cyanogenic glycosides, while antinutrients include phytates, oxalates, phenol and anthocyanin in the ethanol extract of Terminalia catappa endocarp flour. Results of the present study showed a significantly (p<0.05) higher serum aspartate transaminase (35.50±3.86a), alanine transaminase(121.25±3.90a), alkaline phosphatase (51.00±7.36a) activity in the monosodium glutamate-intoxicated rats, implying hepatocellular injury due to increased membrane permeability, but significant (p<0.05) decrease (25.50±1.19b, 61.00±7.71b, 29.65±3.19b) respectively, in the group treated with extract alone, indicating an apparent ameliorative potential of Terminalia catappa endocarp flour extract to improve the functional capacity of the liver associated with their release. Significant (p<0.05) increase in serum total protein concentration in the MSG-treated rats concomitantly administered with 100 mg kg–1 b.wt., of extract was revealed, while bilirubin concentration was significantly (p<0.05) decreased in similar groups compared to other groups, suggesting a protective effect against MSG-induced hepatotoxicity. Co-administration of MSG with varying concentrations of the extract attenuated MSG-induced toxicity in rats. Conclusion: Thus, the extract significantly improved the hepatic indices which possibly revealed that Terminalia catappa endocarp is relatively rich in some vital bioactive constituents, hence, could serve to provide medical or health benefits, as well as, reducing the hitherto waste generated from such inedible part of the fruit.
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How to cite this article:

Anuforo Philemon Chinemezu, Achi Ngozi K, Egbuonu Anthony C. Cemaluk and Egu Elizabeth Uchechi, 2018. Determination of Some Phyto-constituents Present in Terminalia catappa Endocarp Flour and Biochemical Evaluation of its Ethanolic Extract on Hepatic Indices in Male Wistar Rats. Journal of Pharmacology and Toxicology, 13: 27-36.

DOI: 10.3923/jpt.2018.27.36

URL: https://scialert.net/abstract/?doi=jpt.2018.27.36

 
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