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Journal of Pharmacology and Toxicology
  Year: 2017 | Volume: 12 | Issue: 4 | Page No.: 161-169
DOI: 10.3923/jpt.2017.161.169
Antidiabetic Activity and Safety Used of Nutrasucre, a Food Complement, in Alloxan Induced Diabetic Rats
Pierre Manda , Nomane Bernard Goze, Arthur Stephane Gnagne, Alain Didier Abounan, Aholia Jean Baptiste Adepo and Djedje Sebastien Dano

Abstract:
Background and Objective: Type 2 diabetes is one of the major public health problem arround the world and particularly in Cote d'Ivoire. The relation ship between sugar consumption and type 2 diabetes treatment remained critical to be discovered. Nutrasucre, a food complement containing brown sugar and extracts of medicinal plants used for the treatment of type 2 diabetes in Cote d’Ivoire. This study aimed nutrasucre’s aptitude to reduce glycemia and its safety used may provide a likely profit by supporting sugar consumption in type 2 diabetes treatment. Materials and Methods: Thirty five diabetics rats received nutrasucre solution at 1.43, 2.86 and 5.71 g kg–1 b.w., respectively. Blood withdrawals were performed at the end of treatment. Biochemical parameters were assessed: Glycemia, urea, creatinine, transaminases (ALAT, ASAT), triglycerides, total cholesterol, HDL cholesterol and LDL cholesterol. Acute and subacute toxicity were carried out using OECD Guidelines 423 and 407, respectively. Kidneys, heart and liver tissues were collected and subjected to microscopical analysis. One-way analysis of variance (ANOVA 1) and multiple comparisons of Tukey-Kramer post-hoc test were being used. Results: Nutrasucre possessed antihyperglycemic effect comparable to glibenclamide, a reference antihyperglycemic drug and increased triglyceride, total cholesterol, HDL and LDH cholesterols levels. This increase was significant for triglycerides (p<0.05) compared to diabetic controls receiving only the 0.9% NaCl solution. Nutrasucre also decreased ASAT and ALAT serum levels at the three levels tested. The median acute toxicity LD50 value of nutrasucre was higher than 5000 mg kg–1 b.w. and was classified as non toxic in the Globally Harmonized System of Classification and Labelling of Chemicals (GHS). No signs of subacute toxicity were recorded during the 28 observation days. Finally, the repeated administration of nutrasucre did not affect various vital organs. Conclusion: It is concluded that nutrasucre was antihyperglycemic, nontoxic and does not affect vital organs such as kidneys, liver and heart. It reduces serum ASAT, ALAT and total, LDH and HDL levels and contains hypolipidic substances. It can be advised as antidiabetic food complement.
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How to cite this article:

Pierre Manda, Nomane Bernard Goze, Arthur Stephane Gnagne, Alain Didier Abounan, Aholia Jean Baptiste Adepo and Djedje Sebastien Dano, 2017. Antidiabetic Activity and Safety Used of Nutrasucre, a Food Complement, in Alloxan Induced Diabetic Rats. Journal of Pharmacology and Toxicology, 12: 161-169.

DOI: 10.3923/jpt.2017.161.169

URL: https://scialert.net/abstract/?doi=jpt.2017.161.169

 
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