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Journal of Pharmacology and Toxicology
  Year: 2016 | Volume: 11 | Issue: 1 | Page No.: 11-19
DOI: 10.3923/jpt.2016.11.19
 
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Comparative Pharmacokinetics of Intramuscular Sulphadimidine in Non-starved and Starved Grower Turkeys (Meleagris gallopavo)
Agbo Joseph Odeh, Saganuwan Alhaji Saganuwan and Onyeyili Patrick Azubuike

Abstract:
Background: Sulphadimidine has maintained an active place in the armamentary of avian medicine. Objective: In view of this, comparative pharmacokinetic parameters were studied in starved and non-starved grower turkeys. Methodology: In a randomized parallel study, the pharmacokinetics of sulphadimidine sodium (100 mg kg–1 b.wt.) was obtained in non-starved healthy male and female grower turkeys (n = 20) and starved male and female grower turkeys (n = 20) after a single intramuscular administration. The mean peak serum concentrations of sulphadimidine were 99.42±3.81 μg mL–1 at 1.5 h in non-starved male turkeys and 127.68±10.37 μg mL–1 at 2 h in starved male turkeys, respectively. The mean elimination half-lives were 7.62±0.51 and 12.76±1.52 h in non-starved and starved male turkeys, respectively. Results: The mean peak serum concentrations of sulphadimidine were 99.42±3.81 μg mL–1 at 1.5 h in non-starved male turkeys and 127.68±10.37 μg mL–1 at 2 h in starved male turkeys, respectively. The mean elimination half-lives were 7.62±0.51 and 12.76±1.52 h in non-starved and starved male turkeys, respectively. The mean peak serum concentration of sulphadimidine at 2 h (86.70±6.46 μg mL–1) in non-starved and 1.5 h (121.62±8.55 μg mL–1) in starved female turkeys were recorded, respectively. The mean elimination half-lives were 9.99±1.31 and 14.39±1.52 h in non-starved and starved female turkeys, respectively. Based on target MIC of ≥50 μg mL–1 in serum, sulphadimidine was maintained above this level for 10 and 18 h in non-starved and starved male and female Turkeys, respectively. Conclusion: The study indicates that sulphadimidine sodium should be administered to anorexic male and female turkeys infected with coccidia and bacteria sensitive to sulphadimidine every 18 h interval. For prophylaxis, sulphadimidine can be administered intramuscular every 10 h interval.
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How to cite this article:

Agbo Joseph Odeh, Saganuwan Alhaji Saganuwan and Onyeyili Patrick Azubuike, 2016. Comparative Pharmacokinetics of Intramuscular Sulphadimidine in Non-starved and Starved Grower Turkeys (Meleagris gallopavo). Journal of Pharmacology and Toxicology, 11: 11-19.

DOI: 10.3923/jpt.2016.11.19

URL: https://scialert.net/abstract/?doi=jpt.2016.11.19

 
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