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Journal of Pharmacology and Toxicology
  Year: 2016 | Volume: 11 | Issue: 1 | Page No.: 1-10
DOI: 10.3923/jpt.2016.1.10
Hepatoprotective Effects of Bitter Melon and Blueberry Leaf Teas on Endogenous Hepatic Antioxidant Enzymes
S. Willis, J. Boateng , K. Busambwa, L. Shackelford and M. Verghese

Abstract:
Background and Objective: Demand for plant preparations is on the rise urging the need to investigate their potential for toxicity. The aim of this study was to evaluate the effect of oral supplementation of bitter melon (BMLT) and blueberry leaf teas (BLUT) on redox and drug metabolizing enzymes: Glutathione (GSH) levels, Glutathione-S-Transferase (GST), superoxide dismutase (SOD), catalase (CAT) activities were determined. Methodology: Rats (n = 5) were administered once daily by gavages 0, 1000, 2000 and 4000 mg kg–1 b.wt., of BMLT, BLUT for 28 days. Day 29, rats were killed by CO2 asphyxiation and tissue and blood samples were collected for analysis. Results: Results also showed GST, CAT and SOD (μmol mg–1 protein) activities in experimental groups ranged from 0.89-2.14, 0.93-1.38 and 0.35-0.55, respectively. There were no significant differences in GSH (μmol/mg protein) levels between the control and treatment groups. Conclusion: Results indicated BMLT and BLUT prevented oxidative stress by improving the activity of antioxidant enzymes. Results also showed no apparent toxicity in rats administered LHT.
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How to cite this article:

S. Willis, J. Boateng, K. Busambwa, L. Shackelford and M. Verghese, 2016. Hepatoprotective Effects of Bitter Melon and Blueberry Leaf Teas on Endogenous Hepatic Antioxidant Enzymes. Journal of Pharmacology and Toxicology, 11: 1-10.

DOI: 10.3923/jpt.2016.1.10

URL: https://scialert.net/abstract/?doi=jpt.2016.1.10

 
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