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Journal of Pharmacology and Toxicology
  Year: 2014 | Volume: 9 | Issue: 1 | Page No.: 37-45
DOI: 10.3923/jpt.2014.37.45
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Cardioprotective Effects of Bovine Colostrum Against Isoproterenol-induced Myocardial Infarction in Rats

Ginpreet Kaur, Rachana Somaiya, Mohd. Wasim and Harpal S. Buttar

Cardiovascular diseases like hypertension and Myocardial Infarction (MI) are the most important determinants for high mortality rate globally with a prevalence of 12.2% deaths as estimated by the World Health Organization. An Angiotensin Converting Enzyme (ACE) inhibitor, such as enalapril is the commonly used synthetic drug for treating high blood pressure, but may cause side effects like kidney toxicity or diarrhea. Therefore, there exists a need for alternative therapy. Bovine Colostrum (BC) containing several growth and immune factors triggers nearly fifty beneficial processes in newborns showing no side effects. Besides many clinical applications, there is no credible evidence of colostrum showing cardio-protective effect against MI. This study was designed to evaluate the effects of BC alone or in combination with enalapril against isoproterenol-induced myocardial infarction in rats. A dose finding toxicity study with BC (500, 1,000 or 2,000 mg kg-1, p.o.) did not reveal any overt adverse symptoms or mortality in rats dosed for 14 consecutive days. Adult Wistar albino rats were weighed and randomly divided in seven groups where each group consists of six rats. Isoproterenol-induced myocardial infarcted group and group VII were fed with ACE inhibitor enalapril 0.25 mg kg-1. Group III and V were given different doses of colostrum 250 and 500 mg kg-1, respectively, whereas group IV and VI received various doses of colostrum along with ACE inhibitor enalapril to observe the pharmacodynamic interaction. Results obtained from the in vitro DPPH free radical scavenging method and ex vivo lipid peroxidation inhibitory activity by TBARS method indicated that BC possesses significant free radical scavenging activity and causes marked inhibition of lipid peroxidation. In biochemical serum estimation, the activity of various cardiac enzymes such as Lactate Dehydrogenase (LDH) and Creatine Kinase (CK) were determined. The serum levels altered by isoproterenol showed significant restoration by the administration of BC along with enalapril as compared with enalapril alone, suggesting that colostrum seems to have beneficial cardio-protective effects in rats. Additional studies are warranted to verify the results of these preliminary findings.
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How to cite this article:

Ginpreet Kaur, Rachana Somaiya, Mohd. Wasim and Harpal S. Buttar, 2014. Cardioprotective Effects of Bovine Colostrum Against Isoproterenol-induced Myocardial Infarction in Rats. Journal of Pharmacology and Toxicology, 9: 37-45.

DOI: 10.3923/jpt.2014.37.45






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