Submit Manuscript

Journal of Pharmacology and Toxicology

Year: 2014 | Volume: 9 | Issue: 3 | Page No.: 119-128
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend

Total views 483

Search

Authors

R. Surendra Kumar

Aseer Manilal

A. Jamal Abdul Nasser

Behailu Merdekios

Xiangxiong Chen

A. Idhayadhulla

Keywords

Novel diverse 1, 4-dihydropyridine analogues were prepared from cyclization method. Synthesized compounds were characterized from IR, 1H-NMR, 13C-NMR, mass spectral, elemental analysis and mass spectral fragmentation method. The reaction was performed using ordinary condensation type, which enabled to easy work-up and good yield. Synthesized compounds (1-4) were screened for antimicrobial activity. Among these compounds (4) (MIC:8 μg mL-1) has highly antibacterial activity against E. coli compared with standard Ciprofloxacin and compound (4) (MIC: 4 μg mL-1) has highly antifungal active against C. albicans compared with Clotrimazole.The synthesized compounds have been screened for preliminary anti-cancer activity against HepG2 (Liver), Hela (Cervical) and MCF-7 (Breast) cancer cells. The compound (4) is highly active against HepG2, MCF-7 and Hela (Cervical) and these have been selected for advanced preclinical development. Activity has been compared with standard drug. Structure Activity Relationship (SAR) has also been discussed in this study.
PDF Fulltext XML References Citation

How to cite this article

R. Surendra Kumar, Aseer Manilal, A. Jamal Abdul Nasser, Behailu Merdekios, Xiangxiong Chen and A. Idhayadhulla, 2014. Synthesis of Novel and Diverse 1, 4-dihydropyridine Analogues and their Antimicrobial and Anticancer Activities. Journal of Pharmacology and Toxicology, 9: 119-128.

DOI: 10.3923/jpt.2014.119.128

URL: https://scialert.net/abstract/?doi=jpt.2014.119.128

Leave a Comment

Your email address will not be published. Required fields are marked *