The present study aimed to evaluate the pattern of poisoning at a tertiary care hospital in South India and to study the socio-demographic profile of the same. Patients who were admitted to the Intensive Care Unit at SRM Medical College Hospital and Research Center were included in the study. Patients were studied for a period of eight months retrospectively to record the incidence, age, sex, domicile distribution, education, occupation, marital and socioeconomic status. Type of poisoning, various reasons and nature of poisoning were noted. Ethical clearance was obtained before the study and then, data was collected. The data was analyzed using descriptive statistics. The total number of poisoning cases was 261. Demographic details were examined. The type of poisons was founded to be organophosphates, oleander seeds, snake bite, nail polish, rodenticide, alcohol (methanol), antifungal drugs, antipsychotic drugs, ant killer, endosulphan, food, hair dye, kerosene and miscellaneous. The study concludes that poisoning is a communal cause of hospital admissions. The most poisoning cases were observed with pesticides handled by the farmers in the agriculture fields.