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Journal of Pharmacology and Toxicology

Year: 2013 | Volume: 8 | Issue: 3 | Page No.: 82-89
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Authors

Paulo Jose Castro dos Anjos

Paulo Roberto Pereira

Italo Jose Alves Moreira

Mairim Russo Serafini

Adriano Antunes Souza Araujo

Francilene Amaral da Silva

Cledison Santos Ramos

Angelo Roberto Antoniolli

Marcio Roberto Viana dos Santos

Keywords

Bauhinia forficata, known as “pata-de-vaca”, is used in folk medicine as antidiabetic. This study evaluated the phytochemical composition of the aqueous extract of Bauhinia forficata leaves (AEBF) and investigated its antihypertensive effect in conscious normotensive and Goldblatt hypertensive rats. Phytochemical screening of the aqueous extract was performed by colorimetric tests. The Mean Arterial Pressure (MAP) and Heart Rate (HR) were measured in normotensive and hypertensive rats through a catheter inserted in abdominal aorta via femoral artery. Aortic catheter was connected to a pressure transducer coupled to an amplifier-recorded apparatus. Phytochemical screening of the AEBF showed the presence of phenols, flobabenic tannins, flavonols, flavanones, alkaloids and saponins. In normotensive rats, it was observed that AEBF (5, 10, 20 and 40 mg kg-1, i.v.) induced hypotension and tachycardia that were not changed after indomethacin administration but were significantly (p<0.05) attenuated L-NAME. After treatment with atropine, only tachycardia was attenuated. In Goldblatt hypertensive rats, acute treatment with AEBF (400 mg kg-1; v.o.) was able to reduce 12% of the MAP (n = 6), while that HR was not affected. In summary, this study found possible benefits of this plant on the cardiovascular system. The results demonstrate that the Aqueous Extract of Bauhinia forficata (AEBF) present antihypertensive effect that seems to involve releasing of NO.
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How to cite this article

Paulo Jose Castro dos Anjos, Paulo Roberto Pereira, Italo Jose Alves Moreira, Mairim Russo Serafini, Adriano Antunes Souza Araujo, Francilene Amaral da Silva, Cledison Santos Ramos, Angelo Roberto Antoniolli and Marcio Roberto Viana dos Santos, 2013. Antihypertensive Effect of Bauhinia forficata Aqueous Extract in Rats. Journal of Pharmacology and Toxicology, 8: 82-89.

DOI: 10.3923/jpt.2013.82.89

URL: https://scialert.net/abstract/?doi=jpt.2013.82.89

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