Poisoning by various substances is very common. The present study aimed to evaluate the pattern of poisoning admitted to the Intensive Care Unit at SRM Medical College Hospital and Research Center. Cases were studied for a period of one year prospectively to record the incidence, age, sex, domicile distribution, education, occupation, marital and socioeconomic status. Type of poisoning with various reasons and nature of poisoning were noted. Ethical clearance was obtained and data were analyzed using descriptive statistics. The total number of poisoning cases was 224. The various types of poisons found were alcohol, antifungal drugs, antipsychotic drugs, rodenticide, organophosphates, ant killer, endosulphan, food, hair dye, kerosene, multi tablets, nail polish, oleander seeds, petrol, pain killer, Savlon liquid, scorpion bite, thinner, benzodiazepine. Maximum numbers of poisoning were of suicidal cases. Majority of poisoning cases admitted were due to organophosphates followed by oleander seeds. The study concludes that poisoning is a communal cause of hospital admissions. The most poisoning cases were observed with pesticides handled by the farmers in the agriculture fields. Strict policies against the sale and availability of pesticides must be brought in the future and poison control center, patient counseling may have a better fruitful effect in controlling the number of poisoning cases.