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Journal of Pharmacology and Toxicology
  Year: 2012 | Volume: 7 | Issue: 8 | Page No.: 378-385
DOI: 10.3923/jpt.2012.378.385
 
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Acute and Sub Chronic Oral Toxicity Assessment of the Ethanolic Extract from the Rind of Nephelium lappaceum in Rats

Shonia Subramaniam, Srikumar Chakravarthi, Uma Devi Palanisamy, Ammu Radhakrishnan and Nagaraja Haleagrahara

Abstract:
Nephelium lappaceum is a tropical fruit native to Malaysia. The rind of N. lappaceum, is having extremely high antioxidant and free radical scavenging activities. The ethanol extract from the rind of Nephelium lappaceum was evaluated for acute and sub-chronic toxicity study in Sprague Dawley rats. In the acute study, a single oral administration of N. lappaceum rind extract (50, 200, 1000 and 2000 mg kg-1) was administered to rats for 14 days. In the sub chronic toxicity study, the extract was administered to rats (500, 2000 mg kg-1) for 28 days. There was no mortality, or adverse effects observed in rats. There was no significant difference observed in relative organ weights and the biochemical analysis (serum urea, creatinine, ALP, AST and total protein). Histological observation of liver and kidney also did not reveal any significant changes. In conclusion, present study showed that the lethal dose of ethanol extract of Nephelium lappaceum rind is more than 2000 mg kg-1 and there is a huge margin of safety for the therapeutic use. No-observed-adverse-effect-level (NOEL) of the extract is considered to be up to 2000 mg kg-1 day-1 for 28 days in rats.
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How to cite this article:

Shonia Subramaniam, Srikumar Chakravarthi, Uma Devi Palanisamy, Ammu Radhakrishnan and Nagaraja Haleagrahara, 2012. Acute and Sub Chronic Oral Toxicity Assessment of the Ethanolic Extract from the Rind of Nephelium lappaceum in Rats. Journal of Pharmacology and Toxicology, 7: 378-385.

DOI: 10.3923/jpt.2012.378.385

URL: https://scialert.net/abstract/?doi=jpt.2012.378.385

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