Science Alert
Curve Top
Journal of Pharmacology and Toxicology
  Year: 2012 | Volume: 7 | Issue: 8 | Page No.: 359-368
DOI: 10.3923/jpt.2012.359.368
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Antihypertensive Potency of Wild Cosmos (Cosmos caudatus Kunth, Asteraceae) Leaf Extract

Lia Amalia, Kusnandar Anggadiredja, Sukrasno, Irda Fidrianny and Rini Inggriani

The wild cosmos (Cosmos caudatus Kunth, Asteraceae) is one of the vegetables mostly consumed by rural people of Central and East Java Provinces of Indonesia and those of the Malay Peninsula. Yet, it has not been widely used medicinally. The leaf has distinctive taste as well as odor and contains high level of flavonoid, especially flavonol and flavon glycosides which have potent antioxidant activity. In this study, in an attempt to explore the antihypertensive effect, wild cosmos leaf aqueous extract was tested in rats treated with adrenaline and sodium chloride. The frequency of heart rate and amplitude of stroke volume were measured using the non-invasive tail cuff method. The extract at doses of 500 and 1000 mg kg-1 showed similar potency to that of 9 mg kg-1 atenonol, in lowering both parameters, induced by adrenaline. However, after sodium chloride, the extract only suppressed the amplitude and this effect was comparable to that of 0.45 mg kg-1 hydrochlorothiazide and 13.5 mg kg-1 captopril. Besides cardiac effects, the extract also demonstrated diuretic activity which was comparable to that of 1.8 mg kg-1 furosemide. Taken together, results of present study suggest that wild cosmos leaf extract have antihypertensive effect which may be related, at least in part, to the decreased cardiac output and induction of diuresis. The results may further indicate that consumption of wild cosmos leaf in diet is beneficial for hypertensive patients.
PDF Fulltext XML References Citation Report Citation
  •    The Effect of Ethanol Extract of Kucai (Allium schoenoprasum L.) Bulbs on Serum Nitric Oxide Level in Male Wistar Rats
  •    Antioxidant and Antiproliferative Effects of Flavonoids from Emilia sonchifolia Linn on Human Cancer Cells
  •    Vasorelaxant and Hypotensive Effects of Allium cepa Peel Hydroalcoholic Extract in Rat
  •    Hepatoprotective Activity and Flavonoids of Alchornea laxiflora Leaf Extract
  •    Antihypertensive Effects and Antioxidant Action of a Hydro-Alcoholic Extract Obtained from Fruits of Euterpe oleracea Mart. (Acai)
How to cite this article:

Lia Amalia, Kusnandar Anggadiredja, Sukrasno, Irda Fidrianny and Rini Inggriani, 2012. Antihypertensive Potency of Wild Cosmos (Cosmos caudatus Kunth, Asteraceae) Leaf Extract. Journal of Pharmacology and Toxicology, 7: 359-368.

DOI: 10.3923/jpt.2012.359.368






Curve Bottom