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Journal of Pharmacology and Toxicology

Year: 2012 | Volume: 7 | Issue: 6 | Page No.: 298-304
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Authors

A.A. Ayankunle

O.T. Kolawole

A.A. Adesokan

M.O. Akiibinu

Keywords

Research Article

Antibacterial Activity and Sub-chronic Toxicity Studies of Vitellaria paradoxa Stem Bark Extract

A.A. Ayankunle, O.T. Kolawole, A.A. Adesokan and M.O. Akiibinu
This study was designed to assess the antibacterial activity of stem bark extract of Vitellaria paradoxa and its effect on haematological and biochemical parameters. The aqueous and ethanol extracts of stem bark of Vitellaria paradoxa at a concentration of 50 mg mL-1 were tested on clinical isolates of Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Enterococcus faecalis, Staphylococcus aureus, Pseudomonas aeruginosa and Streptococcus pyogenes using agar well-dilution method. The 12 mg kg-1 b.wt. of the ethanol extract was administered for 28 days to a group of rats to assess its effects on the hematological indices, serum levels of creatinine and urea and activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP). The LD50 of the ethanol extract was determined to be 115 mg kg-1 b.wt. in mice. All the bacteria were susceptible except Pseudomonas aeruginosa and Streptococcus pyogenes that showed resistance to both aqueous and ethanol extracts. Ethanol extract was observed to exhibit more antibacterial activity at equivalent dose compared to aqueous extract. All hematological parameters were not significantly altered except the platelet count which was significantly (p<0.05) reduced. Serum levels of creatinine, urea, ALT, AST and ALP were significantly higher (p<0.05) in treated rats compared with control.
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Comments

Okay Odocha, MD Reply

Any known or planned antibacterial comparative studies between the stem bark extract and the Viterallia seeds shea butter extract?

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