Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
Journal of Pharmacology and Toxicology
  Year: 2012 | Volume: 7 | Issue: 5 | Page No.: 231-241
DOI: 10.3923/jpt.2012.231.241
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail
Antiamnesic and Antioxidant Effect of Acacia catechu-catechin in Normal, Aged and Scopolamine Challenged Cognitive Deficit Mice
S.M. Biradar, K.C. Tarak, V.H. Kulkarni, P.V. Habbu and D.M. Smita

Abstract:
In the present study Acacia catechu-Catechin (CTN) was evaluated for antiamnesic and antioxidant activity using various in vivo models. Scopolamine and natural aging were used to induce experimental amnesia in mice. The tested does of CTN (40, 20 and 10 mg kg-1) significantly enhanced the learning capacity and retention of memory in Passive Shock Avoidance and Spatial Water cage exteroceptive behavioural models. Pre-treatment with CTN restored the increased levels of lipid peroxidation and reduced glutathione due to scopolamine and natural aging. A dose dependent CTN (40, 20 and 10 mg kg-1) antioxidant activity of Thiobarbituric acid reactive substances (TBARS) and reduced glutathione (GSH) in whole brain was seen, which were comparable to Standard Piracetam (400 mg kg-1). Hence, it is worthwhile to explore the potential of this Acacia catechu-Catechin in the management of Neurodegenerative disorders of the type Alzheimer’s disease.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Phenols and Polyphenols from Argania spinosa
  •    Hypoglycemic, Hypocholesterolemic and Ocular-protective Effects of an Aqueous Extract of the Rhizomes of Sansevieria senegambica Baker (Agavaceae) on Alloxan-Induced Diabetic Wistar Rats
  •    Preventive Effect of Grape Seed Hydroalcholic Extract on Dementia Type of Alzheimer's Disease in Aged Male Rats
  •    Studies on the Hypotensive, Cardio-suppressant, Vasodilator and Antiplatelet Activities of Betel Nut Crude Extract and its Constituents
How to cite this article:

S.M. Biradar, K.C. Tarak, V.H. Kulkarni, P.V. Habbu and D.M. Smita, 2012. Antiamnesic and Antioxidant Effect of Acacia catechu-catechin in Normal, Aged and Scopolamine Challenged Cognitive Deficit Mice. Journal of Pharmacology and Toxicology, 7: 231-241.

DOI: 10.3923/jpt.2012.231.241

URL: https://scialert.net/abstract/?doi=jpt.2012.231.241

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 

       

       

Curve Bottom