Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
Journal of Pharmacology and Toxicology
  Year: 2012 | Volume: 7 | Issue: 4 | Page No.: 192-198
DOI: 10.3923/jpt.2012.192.198
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Local Anesthetic and Tissue Effects of the Leaf Extract and Fractions of Sterculia tragacantha Lindl

Rita I. Udegbunam, Uzoma I. Asuzu, Raphael O.C. Kene, Sunday O. Udegbunam and Chinaka O. Nwaehujor

Abstract:
The local anesthetic and tissue effects of the leaf extract and fractions of S. tragacantha were evaluated in this study. The extract 10 and 0.03 mg mL-1 produced 100 and 86% anesthesia, respectively while lignocaine 0.1 and 0.03 mg mL-1 produced 94.4 and 69.4% anesthesia respectively. The fractions showed concentration dependent local anaesthetic effect with fraction 5 being the most active fraction. Fractions 5 and 7 were more potent than lignocaine. Histological examination of skin sections of mice taken on days 1 and 5 post injection of S. tragacantha extract did not reveal any sign of tissue reaction. All fractions contained alkaloids and flavonoids. Three fractions (F5, F6 and F7) contained saponins. This study showed that the extract and fractions of S. tragacantha exhibited local anesthetic activity. The alkaloids and saponins contained in the leaves of S. tragacantha may be responsible for this activity.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Modulation of Visceral Nociception by Capsaicin in Mice
  •    Anti-Nociceptive, Anti-Inflammatory and Anti-Oxidant Effects of the Methanol Leaf Extract of Sterculia tragacantha Lindl
How to cite this article:

Rita I. Udegbunam, Uzoma I. Asuzu, Raphael O.C. Kene, Sunday O. Udegbunam and Chinaka O. Nwaehujor, 2012. Local Anesthetic and Tissue Effects of the Leaf Extract and Fractions of Sterculia tragacantha Lindl. Journal of Pharmacology and Toxicology, 7: 192-198.

DOI: 10.3923/jpt.2012.192.198

URL: https://scialert.net/abstract/?doi=jpt.2012.192.198

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 

Curve Bottom