
	Journal of Pharmacology and Toxicology
	Year: 2011 \| Volume: 6 \| Issue: 1 \| Page No.: 82-89 DOI: 10.3923/jpt.2011.82.89

Evaluation of Antioxidant and Antiulcer Activity of Traditionally Consumed Cucumis melo Seeds

N.S. Gill, J. Bajwa, P. Sharma, K. Dhiman, S. Sood, P.D. Sharma, B. Singh and M. Bali

Abstract: The present study was to investigate the anti-ulcer activity of methanolic extract of Cucumis melo (MECM) seeds. The seeds were extracted with methanol and the extract was evaluated for its free radical scavenging activity by DPPH. It shows maximum antioxidant activity. Thus extract was further evaluated against gastric ulcerations by Pyloric Ligation (PL), Water Immersion Stress (WIS) and NSAID (indomethacin) induced ulcer (NIU) models. In case of PL method, the extract inhibited gastric ulcerations in a dose-related manner (150 and 300 mg kg^-1). Then it was evaluated for gastric volume, free acidity, total acidity, ulcerative index. The ulcerative index was also measured in WIS model and NIU with same doses. The MECM caused 57.6, 67.6 and 61.9% inhibition of ulcers in pyloric ligation, water immersion stress, NSAID induced ulcer models respectively at 300 mg kg^-1. The results concluded that MECM possess high antiulcer potential which is due to its higher antioxidant activity.

PDF Fulltext XML References Citation Report Citation

RELATED ARTICLES:

•	Study of Antioxidant, Analgesic and Antiulcer Potential of Trichosanthes cucumerina Ethanolic Seeds Extract

•	Evaluation of Antioxidant and Antiulcer Potentials of Prunus domestica Fruit Methanolic and Extract on Wistar Albino Rats

•	Total Phenolic Content, Total Flavonoid Content, Antioxidant and Antimicrobial Activities of Malaysian Shorea

•	Protective Effect of Zanthoxylum nitidum Bark in Chemical and Stress Induced Gastric Mucosal Lesions in Male Albino Rats

•	Evaluation of Antioxidant and Antiulcer Potential of Cucumis sativum L. Seed Extract in Rats

How to cite this article:

N.S. Gill, J. Bajwa, P. Sharma, K. Dhiman, S. Sood, P.D. Sharma, B. Singh and M. Bali, 2011. Evaluation of Antioxidant and Antiulcer Activity of Traditionally Consumed Cucumis melo Seeds. Journal of Pharmacology and Toxicology, 6: 82-89.

DOI: 10.3923/jpt.2011.82.89

URL: https://scialert.net/abstract/?doi=jpt.2011.82.89

COMMENT ON THIS PAPER

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		ASCI-Database
		Asian Digital Library
		Cambridge Scientific Abstract
		Chemical Abstract Services
		Google Scholar

Science Alert