Effect of Various Levels of Dietary Malathion on Wistar Rats


	Journal of Pharmacology and Toxicology
	Year: 2011 \| Volume: 6 \| Issue: 1 \| Page No.: 69-75 DOI: 10.3923/jpt.2011.69.75

Effect of Various Levels of Dietary Malathion on Wistar Rats

E.H. Abdelgadirand and S.E.I. Adam

Abstract: Malathion is a pesticide that is widely used in agriculture, residential landscaping, public recreation areas and in public health pest control programs such as mosquito eradication, it is the most commonly used organophosphate insecticide. Malathion were fed to 60 day-old Wistar rats at 50, 100, 500, 1000 and 2000 mg kg^-1 of diet for 8 weeks. The 1000 and 2000 mg kg^-1 of dietary Malathion were toxic but not lethal to rats and caused nephrohepatopathy, lymphocytic accumulation in vital organs, after 4 weeks macrocytic hypochromic anaemia and microcytic hypochromic anaemia after 8 weeks. Alterations of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities and cholesterol, globulin and urea concentrations.

PDF Fulltext XML References Citation Report Citation

RELATED ARTICLES:

•	Assessment of Pesticide Residues in Vegetables at the Farm Gate: Cabbage (Brassica oleracea) Cultivation in Cape Coast, Ghana

How to cite this article:

E.H. Abdelgadirand and S.E.I. Adam, 2011. Effect of Various Levels of Dietary Malathion on Wistar Rats. Journal of Pharmacology and Toxicology, 6: 69-75.

DOI: 10.3923/jpt.2011.69.75

URL: https://scialert.net/abstract/?doi=jpt.2011.69.75

COMMENT ON THIS PAPER

	Full Name:
	E-mail:
	Comments:

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		ASCI-Database
		Asian Digital Library
		Cambridge Scientific Abstract
		Chemical Abstract Services
		Google Scholar

Follow @scialert

Science Alert