Effect of Various Levels of Dietary Malathion on Wistar Rats


	Journal of Pharmacology and Toxicology
	Year: 2011 \| Volume: 6 \| Issue: 1 \| Page No.: 69-75 DOI: 10.3923/jpt.2011.69.75

Effect of Various Levels of Dietary Malathion on Wistar Rats

E.H. Abdelgadirand and S.E.I. Adam

Abstract: Malathion is a pesticide that is widely used in agriculture, residential landscaping, public recreation areas and in public health pest control programs such as mosquito eradication, it is the most commonly used organophosphate insecticide. Malathion were fed to 60 day-old Wistar rats at 50, 100, 500, 1000 and 2000 mg kg^-1 of diet for 8 weeks. The 1000 and 2000 mg kg^-1 of dietary Malathion were toxic but not lethal to rats and caused nephrohepatopathy, lymphocytic accumulation in vital organs, after 4 weeks macrocytic hypochromic anaemia and microcytic hypochromic anaemia after 8 weeks. Alterations of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities and cholesterol, globulin and urea concentrations.

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How to cite this article:

E.H. Abdelgadirand and S.E.I. Adam, 2011. Effect of Various Levels of Dietary Malathion on Wistar Rats. Journal of Pharmacology and Toxicology, 6: 69-75.

DOI: 10.3923/jpt.2011.69.75

URL: https://scialert.net/abstract/?doi=jpt.2011.69.75

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