Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
Journal of Pharmacology and Toxicology
  Year: 2011 | Volume: 6 | Issue: 7 | Page No.: 624-636
DOI: 10.3923/jpt.2011.624.636
Antioxidant and Anticoagulant Properties of Phyllanthus fraternus GL Webster (Family: Euphorbiaceae)
G.A. Koffuor and P. Amoateng

Abstract:
The aim of this study was to investigate the antioxidant and anticoagulant activities of the ethanolic extract of Phyllanthus fraternus. The antioxidant and anticoagulant activity of an ethanolic extract of Phyllanthus fraternus (gulf leaf-flower) was evaluated using in vitro and in vivo experimental models. The results obtained indicate that the extract of P. fraternus (PFE) exhibits antioxidant activity by significantly scavenging 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals, concentration-dependent reducing capacity and inhibition of lipid peroxidation. Detection of phenols in the extract gave preliminary evidence of its possible antioxidant activity which correlated with the total antioxidant capacity. The extract significantly increased in vitro clotting time and bleeding time in rabbits. Heparin and aspirin exhibited similar effects. Since thrombus formation and oxidative stress are known to be main risk factors contributing to stroke, the anticoagulant and antioxidant activity in the plants makes it useful as adjuncts in the management of stroke and other neurodegenerative disorders.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Synthesis of Some Pyrrole Derivatives and their Anticoagulant Activity
  •    Effect of Green and Black Teas on Immobilization Induced Stress in Male Wistar Albino Rats
  •    Polyphenol Contents and Antioxidant Activities of Extracts from Flowers of Two Crataegus azarolus L. Varieties
  •    Modulatory Effects of Ascorbic Acid and α-tocopherol on Arsenic Induced Micronuclei Formation
  •    Antioxidant and Antiproliferative Effects of Flavonoids from Emilia sonchifolia Linn on Human Cancer Cells
How to cite this article:

G.A. Koffuor and P. Amoateng, 2011. Antioxidant and Anticoagulant Properties of Phyllanthus fraternus GL Webster (Family: Euphorbiaceae). Journal of Pharmacology and Toxicology, 6: 624-636.

DOI: 10.3923/jpt.2011.624.636

URL: https://scialert.net/abstract/?doi=jpt.2011.624.636

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 

       

       

Curve Bottom