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Journal of Pharmacology and Toxicology

Year: 2011 | Volume: 6 | Issue: 6 | Page No.: 602-607
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Authors

S.O. Kolawole

O.T. Kolawole

M.A. Akanji

Keywords

Research Article

Effects of Aqueous Extract of Khaya senegalensis Stem Bark on Biochemical and Hematological Parameters in Rats

S.O. Kolawole, O.T. Kolawole and M.A. Akanji
In this study, the effects of aqueous extract of Khaya senegalensis stem bark on hematological and biochemical parameters were investigated in rats. The rats were randomly divided into four groups of 5 rats per group. Group I (control) received normal saline while Groups II, III and IV were fed 50, 100 and 200 mg kg-1 of Khaya senegalensis stem bark extract orally for 21 days. Repeated administration of the extract resulted in a dose-dependent increase in total protein, globulin, urea and creatinine. The extract also produced an increase in the plasma levels of some liver enzymes namely Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT) and Alkaline Phosphatase (ALP). These changes were significant (p<0.05) with 100 and 200 mg kg-1 of the extract. At this same dose range, the extract caused a significant decrease in Red Blood Cells (RBC), Packed Cell Volume (PCV) and Hemoglobin level (Hb). In contrast, serum sodium ion (Na+) and potassium (K+) ion concentrations were elevated following the administration of the extract but there were no significant changes in the serum chloride (Cl¯) and bicarbonate ions (HCO3¯) concentrations. The results of this study suggest that prolonged use of aqueous extract of Khaya senegalensis stem bark extract may adversely affect vital organs in the body.
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