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Journal of Pharmacology and Toxicology
  Year: 2011 | Volume: 6 | Issue: 4 | Page No.: 381-390
DOI: 10.3923/jpt.2011.381.390
Reduction in Platelet Aggregation (in vitro) by Diallyl Sulphide in Female Participants with Type 2 Diabetes Mellitus
Abhaykumar , K. Nirmala, M.P.R. Prasad, Virendra V. Panpatil, T. Prasanna Krishna, B. Sesikeran and K. Polasa

Abstract:
Diallyl sulphide an active principle of garlic has been shown to have many medicinal properties. Thus present study is undertaken to see the effect of diallyl sulphide on platelet aggregation in women participants with type 2 diabetes mellitus. Women participants (18) with type 2 diabetes mellitus with >2 years duration formed the study group. The body mass index of the study group was 26±3.4 kg m-2 and age was 47±8.1 years. Platelet aggregation induced by adenosine diphosphate at 10 and 20 μM concentration was measured in platelet rich plasma. The effect of diallyl sulphide (2.2 μg) on platelet aggregation was seen after 1 min of incubation with platelet rich plasma. The women participants were divided into two groups (fast responders for adenosine diphosphate induced aggregation >5.0% slow responders aggregation <5.0%) based on maximal aggregation percentage. The participants had high abdominal circumference (102±9.4) and were hypertensive. Glucose (162.5±47.18) and glycosylated hemoglobin levels (11.7±2.82) suggest lack of metabolic control. The triglycerides levels (185±58.53) were also high. The platelet aggregation with adenosine diphosphate showed variation (10 μM adenosine diphosphate 2.0-81.0% and 20 μM adenosine diphosphate 9.0-93.0%) in fast responders group. The reduction in platelet aggregation with diallyl sulphide also varied with the participants. The relative reduction of adenosine diphosphate induced aggregation with aspirin ranged from 1.0-65.0%. The fibrinogen levels were in normal range. There was reduction in adenosine induced platelet aggregation by diallyl sulphide. The relative reduction in platelet aggregation by diallyl sulphide as compared to aspirin was higher in four participants in fast responder participants. The data unequivocally demonstrated the platelet aggregation inhibition properties of diallyl sulphide.
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How to cite this article:

Abhaykumar , K. Nirmala, M.P.R. Prasad, Virendra V. Panpatil, T. Prasanna Krishna, B. Sesikeran and K. Polasa, 2011. Reduction in Platelet Aggregation (in vitro) by Diallyl Sulphide in Female Participants with Type 2 Diabetes Mellitus. Journal of Pharmacology and Toxicology, 6: 381-390.

DOI: 10.3923/jpt.2011.381.390

URL: https://scialert.net/abstract/?doi=jpt.2011.381.390

 
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