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Journal of Pharmacology and Toxicology
  Year: 2011 | Volume: 6 | Issue: 1 | Page No.: 24-29
DOI: 10.3923/jpt.2011.24.29
 
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Pathways of Hepatic Regeneration and Pharmacological Approaches for Hepatoprotection: A Brief Approach
J.A. Ansari and M. Jamil

Abstract:
Liver is one of the most important organs in the metabolism of food, drugs, endogenous and exogenous substances. Problems related to liver such as acute or chronic inflammation, toxin-/drugs-induced hepatitis, cirrhosis and hepatitis are well-known nowadays due to our exposure to different environmental pollutants like chemicals, toxins, viruses etc. Liver disease can result from dosage-dependent hepatotoxicity or from adverse reactions to drugs used in therapeutic dosage. The anatomical structures of a liver that has undergone partial hepatectomy are therefore distinctly different from those of the original liver. The restoration process of liver volume in humans is initiated by the replication of various types of intra hepatic cells, followed by an increase in cell size. Efforts to develop pharmacologic means for liver protection from damage during regeneration have identified a few molecular targets.
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How to cite this article:

J.A. Ansari and M. Jamil, 2011. Pathways of Hepatic Regeneration and Pharmacological Approaches for Hepatoprotection: A Brief Approach. Journal of Pharmacology and Toxicology, 6: 24-29.

DOI: 10.3923/jpt.2011.24.29

URL: https://scialert.net/abstract/?doi=jpt.2011.24.29

 
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