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Journal of Pharmacology and Toxicology

Year: 2011 | Volume: 6 | Issue: 2 | Page No.: 182-188
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Authors

T. Gusdinar

R. Herowati

R.E. Kartasasmita

I.K. Adnyana

Keywords

Research Article

Anti-inflammatory and Antioxidant Activity of Quercetin-3, 3’, 4’-Triacetate

T. Gusdinar, R. Herowati, R.E. Kartasasmita and I.K. Adnyana
Quercetin (3,5,7,3',4'-pentahydroxyflavone) was chosen as the lead compound in development of the anti-inflammatory agent due to its low gastric ulcer side effect in addition to its COX-2 and iNOS inhibitory activities. This study aims to obtain data showing antioxidant potency and anti-inflammatory activity of quercetin-3, 3’ and 4’-triacetate. Antioxidant potency was determined by DPPH radical scavenging and lipid peroxidation inhibitory methods, while anti-inflammatory activity was determined using carrageenan induced-rat paw oedema test. The results showed that the anti-inflammatory activity of quercetin-3, 3’ and 4’-triacetate was significantly higher than that of quercetin. Percentage of oedema inhibition of quercetin-3, 3’, 4’-triacetate and quercetin was 14-49 and 2-8%, respectively. However antioxidant activity of quercetin-3, 3’ and 4’-triacetate was lower than that of quercetin. IC50 of quercetin-3, 3’, 4’-triacetate and quercetin applying DPPH radical scavenging method was 325.57 and 16.23, respectively, while that of lipid peroxidation inhibitory method was 161.5 and 5.25, respectively.
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