• [email protected]
  • +971 507 888 742
Submit Manuscript
SciAlert
  • Home
  • Journals
  • Information
    • For Authors
    • For Referees
    • For Librarian
    • For Societies
  • Contact
  1. Journal of Pharmacology and Toxicology
  2. Vol 6 (2), 2011
  3. 182-188
  • Online First
  • Current Issue
  • Previous Issues
  • More Information
    Aims and Scope Editorial Board Guide to Authors Article Processing Charges
    Submit a Manuscript

Journal of Pharmacology and Toxicology

Year: 2011 | Volume: 6 | Issue: 2 | Page No.: 182-188
DOI: 10.3923/jpt.2011.182.188

Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend



Total views 253

Authors


T. Gusdinar

Country: Indonesia

R. Herowati

Country: Indonesia

R.E. Kartasasmita

Country: Indonesia

I.K. Adnyana

Country: Indonesia

Keywords


  • Anti-inflammatory
  • DPPH radical scavenger
  • lipid peroxidation
  • quercetin
  • quercetin-3
  • 3`
  • 4`-triacetate, rat paw oedema
Research Article

Anti-inflammatory and Antioxidant Activity of Quercetin-3, 3’, 4’-Triacetate

T. Gusdinar, R. Herowati, R.E. Kartasasmita and I.K. Adnyana
Quercetin (3,5,7,3',4'-pentahydroxyflavone) was chosen as the lead compound in development of the anti-inflammatory agent due to its low gastric ulcer side effect in addition to its COX-2 and iNOS inhibitory activities. This study aims to obtain data showing antioxidant potency and anti-inflammatory activity of quercetin-3, 3’ and 4’-triacetate. Antioxidant potency was determined by DPPH radical scavenging and lipid peroxidation inhibitory methods, while anti-inflammatory activity was determined using carrageenan induced-rat paw oedema test. The results showed that the anti-inflammatory activity of quercetin-3, 3’ and 4’-triacetate was significantly higher than that of quercetin. Percentage of oedema inhibition of quercetin-3, 3’, 4’-triacetate and quercetin was 14-49 and 2-8%, respectively. However antioxidant activity of quercetin-3, 3’ and 4’-triacetate was lower than that of quercetin. IC50 of quercetin-3, 3’, 4’-triacetate and quercetin applying DPPH radical scavenging method was 325.57 and 16.23, respectively, while that of lipid peroxidation inhibitory method was 161.5 and 5.25, respectively.
PDF Fulltext XML References Citation

How to cite this article

T. Gusdinar, R. Herowati, R.E. Kartasasmita and I.K. Adnyana, 2011. Anti-inflammatory and Antioxidant Activity of Quercetin-3, 3’, 4’-Triacetate. Journal of Pharmacology and Toxicology, 6: 182-188.

DOI: 10.3923/jpt.2011.182.188

URL: https://scialert.net/abstract/?doi=jpt.2011.182.188

Related Articles

Evaluation of Antioxidant and Antiulcer Potentials of Prunus domestica Fruit Methanolic and Extract on Wistar Albino Rats
Efficacy and Safety of Diclofenac Sodium and Aceclofenac in Controlling Post Extraction Dental Pain: A Randomised Open Label Comparative Study
Evaluation of Free Radical Scavenging Activity of Pandanus odoratissimus

Leave a Comment


Your email address will not be published. Required fields are marked *

Useful Links

  • Journals
  • For Authors
  • For Referees
  • For Librarian
  • For Socities

Contact Us

Office Number 1128,
Tamani Arts Building,
Business Bay,
Deira, Dubai, UAE

Phone: +971 507 888 742
Email: [email protected]

About Science Alert

Science Alert is a technology platform and service provider for scholarly publishers, helping them to publish and distribute their content online. We provide a range of services, including hosting, design, and digital marketing, as well as analytics and other tools to help publishers understand their audience and optimize their content. Science Alert works with a wide variety of publishers, including academic societies, universities, and commercial publishers.

Follow Us
© Copyright Science Alert. All Rights Reserved