
	Journal of Pharmacology and Toxicology
	Year: 2011 \| Volume: 6 \| Issue: 2 \| Page No.: 141-148 DOI: 10.3923/jpt.2011.141.148

In vivo Study on Lead, Cadmium and Zinc Supplementations on Spermatogenesis in Albino Rats

A.M. Abdella, B.H. Elabed, A.O. Bakhiet, W.S.A. Gadir and S.E.I. Adam

Abstract: This study was designed to elucidate the mechanisms accounting for disruption of the normal spermatogenesis in the testis, exposed to various levels of cadmium (Cd), lead (Pb) and zinc (Zn). Forty two mature male Albino rats, were divided into six groups; group 1 treated with 100 mg Cd kg^-1 diet, group 2 treated with 5 mg Pb kg^-1 diet, group 3 with 50 mg Zn kg^-1 diet, group 4 treated with mixture of 5 mg Pb +50 mg Cd kg^-1 diet, group 5 treated with 50 mg Cd + 25 mg Zn kg^-1 diet and group 6 treated with 5 mg Pb +25 mg Zn kg^-1 diet for three month. Group 7 was kept as control. Significant increased (p<0.05), of both blood Cd and Pb with loss of both weight and hair associated with testicular enlargement in rats dosed with Cd and/or Pb in the diet. As a consequence these groups showed blockage of spermatogenesis at seminiferous tubules level, maturation arrest and proliferation of the sertoli cells. Where as the group treated with Zn, showed increased weight and increased number of germs cells and developing spermatide in the testicular level. The combined diet of Cd with Pb in one dose exacerbated the toxic action of these elements. While mixing of Zn with Cd and Pb reduced the toxicity of these elements and their effects on development of the germ cell and the proliferation of the sertoli cells.

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How to cite this article:

A.M. Abdella, B.H. Elabed, A.O. Bakhiet, W.S.A. Gadir and S.E.I. Adam, 2011. In vivo Study on Lead, Cadmium and Zinc Supplementations on Spermatogenesis in Albino Rats. Journal of Pharmacology and Toxicology, 6: 141-148.

DOI: 10.3923/jpt.2011.141.148

URL: https://scialert.net/abstract/?doi=jpt.2011.141.148

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