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Journal of Pharmacology and Toxicology

Year: 2011 | Volume: 6 | Issue: 1 | Page No.: 1-17
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Authors

Aman Upaganlawar

Hardik Gandhi

R. Balaraman

Keywords

Research Article

Isoproterenol Induced Myocardial Infarction: Protective Role of Natural Products

Aman Upaganlawar, Hardik Gandhi and R. Balaraman
Cardiovascular Diseases (CVD) remain one of the leading causes of deaths despite several advancements in the medical interventions. Among these, the ischemic heart diseases, acute myocardial infarction (AMI) in particular, is one of the most alarming values. AMI, which arises out of a lot risk-factors working in concert, gives rise to a lot of unfavorable biochemical outcomes. The end-result of which is the ultimate morbidity of the patient or even death. The synthetic drugs that constitute the current pharmacological armamentarium are themselves effective in managing the condition but not without setbacks. These hunches have accelerated the need for natural products, which may be used as dietary supplement to prevent the development of an acute myocardial infarction. The isoproterenol-induced myocardial infarction in rodents offers a relevant model to study the effect of natural products. The model is simple in execution and the biochemical, histological and electrocardiographic changes closely mimic that seen in case of an AMI. The model has so far been widely used by many researchers to study the effect of drugs in AMI. Natural products, which include crude herbals, extracts, herbomineral formulations, polyherbal formulations, etc., have been used for the treatment of ischemic heart diseases in traditional systems of medicine. A range of natural products have been tried for activity against acute myocardial infarction with considerable success. The colossal collections of chemicals present in the natural products possess antioxidant, anti-inflammatory and other properties that prove useful in ameliorating the pathophysiology of acute myocardial infarction. Besides, these natural products may also augment the conventional treatment and offer better management of the condition with fewer side effects.
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