The aim of this perceptive is to call attention to possible interaction between sesame oil or its lignans and drugs. Sesame oil is used extensively in the world especially in the Asian cuisine and it consumption by human is increasing because of its health benefits. In addition, the oil is used widely in the some injectable drug formulations. The lignans such as sesamin, episesamin, sesaminol and sesamolin are major constituents of sesame oil and all have chemically methylenedioxyphenyl group. Although, it was shown that piperonyl butoxide and safrole interact with some P450 isozymes both in insects and mammalian species due to having methylenedioxyphenyl group, there is no data available on the literature on the interaction between sesame oil or its lignans and drugs. According to my hypothesis sesame oil could interact with the P450 isozymes and affect the drug metabolisms or dispositions in human.