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Journal of Pharmacology and Toxicology
  Year: 2010 | Volume: 5 | Issue: 7 | Page No.: 324-333
DOI: 10.3923/jpt.2010.324.333
Evaluation of Toxicological Activity (Acute and Sub-Chronic Toxicities) of the Aqueous Extract of Lawsonia inermis Seeds on Wistar Rats
E.H. Abdelgadir, R.H. Ahmed, S.I.Y. Adam and A.M. Husein

Abstract:
This study was carried out on the effect of aqueous extract of Lawsonia inermis seeds on rats. The 78.57 mg kg-1 of the extract administered for 4 weeks, caused body weight gain to rats and a significant decrease on hematological parameters and potassium concentration. Also there was a significant increase in the AST, ALP, total protein, albumin and urea concentrations with no obvious histopathological changes. 78.57, 392 and 785.7 mg/kg/day administered orally to rats for 1 week, caused an increase in AST, ALP and total protein concentrations. 785.7 mg kg-1 of the extract caused an increase in the ALT activity and a decrease in the potassium concentration. 78.57 and 785.7 mg kg-1 of the extract caused an increase in urea and cholesterol concentrations, while 392 and 785.7 mg kg-1 of the extract had caused hepatocytic necrosis, dilatation of the renal tubules and desquamation of the intestinal epithelium.
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How to cite this article:

E.H. Abdelgadir, R.H. Ahmed, S.I.Y. Adam and A.M. Husein, 2010. Evaluation of Toxicological Activity (Acute and Sub-Chronic Toxicities) of the Aqueous Extract of Lawsonia inermis Seeds on Wistar Rats. Journal of Pharmacology and Toxicology, 5: 324-333.

DOI: 10.3923/jpt.2010.324.333

URL: https://scialert.net/abstract/?doi=jpt.2010.324.333

 
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