CNS Activity of Methanol and Acetone Extracts of Acorus calamus Leaves in Mice


	Journal of Pharmacology and Toxicology
	Year: 2009 \| Volume: 4 \| Issue: 2 \| Page No.: 79-86 DOI: 10.3923/jpt.2009.79.86

CNS Activity of Methanol and Acetone Extracts of Acorus calamus Leaves in Mice

V. Pandy, N. Jose and H. Subhash

Abstract: The present study was designed to evaluate CNS depression or analeptic activity of acute oral administration of methanol (ACME) and acetone (ACAE) extracts of Acorus calamus leaves in mice. Spontaneous locomotor activity, immobility time using forced swim test, diazepam-induced sleeping time and motor impairment assessment using rotarod were used to assess CNS depression/analeptic activity of ACME and ACAE in mice. The extracts ACME (5, 20 and 50 mg kg^-1, p.o.) and ACAE (20 and 50 mg kg^-1, p.o.) significantly decreased the spontaneous locomotor activity in dose dependent manner. The acute treatment of ACME and ACAE (5, 20 and 50 mg kg^-1, p.o.) significantly increased the immobility time and decreased the swimming behavior. Administration [6 h prior] of ACME (50 mg kg^-1, p.o.) and ACAE (20 and 50 mg kg^-1, p.o.) significantly potentiated the diazepam (25 mg kg^-1, i.p.)-induced sleeping time in mice. These extracts did not induce disturbance in motor coordination. The results of the present research provided evidences that ACME and ACAE may contain psychoactive substances that are CNS depressant in nature. The CNS depression property of these extracts can be utilized for further anticonvulsant research.

PDF Fulltext XML References Citation Report Citation

RELATED ARTICLES:

•	The Effects of Ziprasidone on Motor Functions in Experimental Parkinson Model in Mice

•	Isolation, Characterization and Pharmacological Evaluation of 8-chloro-3 (1-methyl-piperidene-4-yl) 5H-benzo [5, 6] Cyclohepta [1, 2b] Pyridene-11(6H)-one from Loratadine

•	Depression-like Effect of Telmisartan in Mice Forced Swim Test: Involvement of Brain Monoaminergic System

•	Anti-cancerous Plants of Uttarakhand Himalaya: A Review

How to cite this article:

V. Pandy, N. Jose and H. Subhash, 2009. CNS Activity of Methanol and Acetone Extracts of Acorus calamus Leaves in Mice. Journal of Pharmacology and Toxicology, 4: 79-86.

DOI: 10.3923/jpt.2009.79.86

URL: https://scialert.net/abstract/?doi=jpt.2009.79.86

COMMENTS

23 October, 2009
vamsi krishna.a:
respected sir's
i would like to know more information about CNS Activity of Acorus calamus Leaves in Mice

REPLY

COMMENT ON THIS PAPER

	Full Name:
	E-mail:
	Comments:

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		ASCI-Database
		Asian Digital Library
		Cambridge Scientific Abstract
		Chemical Abstract Services
		Google Scholar

Follow @scialert

Science Alert