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Journal of Pharmacology and Toxicology
  Year: 2009 | Volume: 4 | Issue: 4 | Page No.: 167-172
DOI: 10.3923/jpt.2009.167.172
 
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Hepatoprotective Activity of Aqueous and Methanolic Extracts of Capparis decidua Stems Against Carbon Tetrachloride Induced Liver Damage in Rats

S.A. Ali, T.H. Al-Amin, A.H. Mohamed and A.A. Gameel

Abstract:
The aqueous and methanolic extracts of Capparis decidua stems locally known as Altoundob were screened for their hepatoprotective activity against CCl4-induced hepatotoxicity in rats. This plant is used in traditional system medicine in the treatment of jaundice. Yet, no systematic studies on its hepatoprotective activity have been reported. The hepatotoxicity produced by administration of CCl4 in paraffin oil (1:9 v/v) at a dose of 0.2 mL kg-1 for 10 days, was found to be inhibited by simultaneous oral administration of aqueous and methanolic extracts of C. decidua stems (200, 400 mg kg-1 b.wt.) for 10 days, with evidence of decreased level of serum aspartate amino transferase, alanine amino transferase, alkaline phosphatase and bilirubin. In addition, the concurrent administration of both extracts with CCl4 for 10 days masked the liver fatty changes induced by the hepatotoxic compound observed in the intoxicated control rats. The results were compared with the hepatoprotective effect of the standard drug silymarin. The preliminary phytochemical screening of the powdered plant showed the presence of alkaloids, flavonoids, tannins, sterols, saponins, cyanogenic glycosides and cumarins as major conistituents of the studied extracts. The results of this study indicated that aqueous and methanolic extracts of C. decidua stems could afford a significant protection against CCl4-induced hepatotoxicity in rats.
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How to cite this article:

S.A. Ali, T.H. Al-Amin, A.H. Mohamed and A.A. Gameel, 2009. Hepatoprotective Activity of Aqueous and Methanolic Extracts of Capparis decidua Stems Against Carbon Tetrachloride Induced Liver Damage in Rats. Journal of Pharmacology and Toxicology, 4: 167-172.

DOI: 10.3923/jpt.2009.167.172

URL: https://scialert.net/abstract/?doi=jpt.2009.167.172

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