Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
Journal of Pharmacology and Toxicology
  Year: 2009 | Volume: 4 | Issue: 4 | Page No.: 160-166
DOI: 10.3923/jpt.2009.160.166
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail
Protective Effect of Moringa oleifera Lam. and Lannea kerstingii Extracts Against Cadmium and Ethanol-induced Lipid Peroxidation
A. Diallo, K. Eklu-Gadegkeku, T. Mobio, S. Moukha, A. Agbonon, K. Aklikokou, E.E. Creppy and M. Gbeassor

Abstract:
The present study had evaluated the protective effect of hydroalcoholic (50-50: v/v) and aqueous extracts of L. kerstingii and M. oleifera against lipid peroxidation induced in vivo and in vitro by either cadmium or ethanol. In a first series of experiments, lipid peroxidation induced in vitro by cadmium (5 μg mL-1) is decreased by hydroalcoholic extracts of M. oleifera and L. kerstingii (100 μg mL-1) by 94% and 50% (p<0.001) respectively whereas their aqueous extracts (100 μg mL-1) reduced the cadmium induced lipid peroxidation by 94% (p<0.001) and 44% (p<0.001) respectively. In vivo, the pretreatment with hydroalcoholic extracts of M. oleifera and L. kerstingii at 1 g kg-1 b.wt. reduced significantly ethanol-induced lipid peroxidation, in liver, by 53 and 50% (p<0.001), respectively. Similar results were found in the kidney even though lipid peroxidation is slightly increased by ethanol in this organ.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Effect of Methanolic Leaf Extract of Ocimum gratissimum (Linn) Leaves on Sodium Arsenite-Induced Toxicity in Rats
  •    Protective Activity of Fumaria vaillantii Extract and Monomethyl Fumarate on Acetaminophen Induced Hepatotoxicity in Mice
  •    Aqueous Extract of Iranian Green Tea Prevents Lipid Peroxidation and Chronic Ethanol Liver Toxicity in Rat
  •    Evaluation of Anti-asthmatic Activities of Ixora coccinea Linn (Rubiaceae)
How to cite this article:

A. Diallo, K. Eklu-Gadegkeku, T. Mobio, S. Moukha, A. Agbonon, K. Aklikokou, E.E. Creppy and M. Gbeassor, 2009. Protective Effect of Moringa oleifera Lam. and Lannea kerstingii Extracts Against Cadmium and Ethanol-induced Lipid Peroxidation. Journal of Pharmacology and Toxicology, 4: 160-166.

DOI: 10.3923/jpt.2009.160.166

URL: https://scialert.net/abstract/?doi=jpt.2009.160.166

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 

       

       

Curve Bottom