Subscribe Now Subscribe Today
Science Alert
Curve Top
Journal of Pharmacology and Toxicology
  Year: 2009 | Volume: 4 | Issue: 4 | Page No.: 152-159
DOI: 10.3923/jpt.2009.152.159
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Anti Inflammatory, Antinociceptive and Central Nervous System Depressant Activities of Marine Bacterial Extracts

M. Santhana Ramasamy and S. Senthil Kumar

The main objective of this study is to isolate the bacterial strains which are producing biomedicinally relevant secondary metabolites. To achieve this, the ethyl acetate extracts of four marine bacterial strains BR1, PC4, EM13 and EM14 which were isolated from Balanus amphitrite (barnacle), Polyclinum constellatum (ascidian) and Enteromorpha compressa (Seaweed), respectively subjected to study the anti inflammatory, analgesic and central nervous system depressant activities. Anti inflammatory activity was studied by carragennan induced rat paw edema model. Though the results were significant (p<0.05) for all the four bacterial extracts the more effective anti-inflammatory activity was exhibited by EM13 and EM14 (range between 20-59% of inhibition). Interestingly EM13 inhibited early phases, whereas EM14 inhibited the later phases of inflammation. These two extracts produced the same effect on analgesic activity which was studied by using hotplate test. However, the ethyl acetate extracts of EM13 and BR1 showed remarkable reduction in locomotor activity and prolongation of phenobarbitone sodium induced sleeping time that demonstrated the significant CNS depressant activity. The experimental data identified that the strains EM13, EM14 and BR1 contain potential pharmacologically active compounds and suggested that to further isolation and characterization of active principles and phylogenetic identification of the epibiotic bacterial strains. The present study evidenced that the bacteria associated with marine organisms are the potential sources of pharmacologically active natural products.
PDF Fulltext XML References Citation Report Citation
  •    Anti-inflammatory, Analgesic, Anti-pyretic, Anti-ulcer and CNS Stimulant Activities of Marine Fungi Aspergillus oryzae
  •    Isolation and Identification of Bacillus altitudinis ZJ 186 from Marine Soil Samples and its Antifungal Activity Against Magnaporthe oryzae
  •    Antimicrobial Activity of Seaweeds Against Multi Drug Resistant Strains
How to cite this article:

M. Santhana Ramasamy and S. Senthil Kumar, 2009. Anti Inflammatory, Antinociceptive and Central Nervous System Depressant Activities of Marine Bacterial Extracts. Journal of Pharmacology and Toxicology, 4: 152-159.

DOI: 10.3923/jpt.2009.152.159






Curve Bottom