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Journal of Pharmacology and Toxicology
  Year: 2009 | Volume: 4 | Issue: 3 | Page No.: 132-137
DOI: 10.3923/jpt.2009.132.137
 
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In vitro Evaluation of Lozenges Containing Extracts of Roots of Zapoteca portoricensis (FAM: Fabaceae)

C.O. Esimone, P.U. Onuh, N.C. Obitte, M.K. Egege and K.C. Ugoeze

Abstract:
The aim of this research was to formulate Zapoteca portoricensis root extract as Lozenges and to evaluate some of their antimicrobial and tablet properties. The root extracts were formulated into Lozenges using either Sodium Carboxy Methyl Cellulose (SCMC) or Carboxy Methyl Cellulose (CMC) as binders. Uniformity of weight, crushing strength, microbial sensitivity and pre-extinction time studies (using E. coli, S. aureus and Candida albicans) were conducted on three Lozenges formulated with either SCMC (Batch A), CMC (Batch B) and a reference standard, DequadinR, containing dequalinium hydrochloride (Batch C). Results showed that Batches B and C passed the weight uniformity test. The three batches had mean crushing strengths of 4.86±0.043, 3.9±0.03 and 13.1±0.43 KgF, respectively for A, B and C. S. aureus and Candida albicans were sensitive to the test lozenges whereas Escherichia coli was not. Candida albicans was minimally sensitive to the standard lozenge, while S. aureus was not. Both the test and the standard samples showed extinction times greater than 30 min.
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How to cite this article:

C.O. Esimone, P.U. Onuh, N.C. Obitte, M.K. Egege and K.C. Ugoeze, 2009. In vitro Evaluation of Lozenges Containing Extracts of Roots of Zapoteca portoricensis (FAM: Fabaceae). Journal of Pharmacology and Toxicology, 4: 132-137.

DOI: 10.3923/jpt.2009.132.137

URL: https://scialert.net/abstract/?doi=jpt.2009.132.137

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