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Journal of Pharmacology and Toxicology
  Year: 2008 | Volume: 3 | Issue: 2 | Page No.: 84-92
DOI: 10.3923/jpt.2008.84.92
Hydro-Alcoholic Media: An Emerging in vitro Tool for Predicting Dose Dumping from Controlled Release Matrices
M.O. Emeje, P.I. Nwabunike , C.Y. Isimi , O.O. Kunle and S.I. Ofoefule

Abstract:
In present study, the release profiles of hydrochlorothiazide from polyacrylic acid polymer (carbopol 71G) matrices in hydro-ethanolic media were done. Percent drug released increased with increasing levels of ethanol in the dissolution media, but there was no direct correlation with the drug`s solubility in the media. Although, the result showed that an initial rapid release was observed in the media containing 30% ethanol, this could not be regarded as dose dumping of hydrochlorothiazide. Release in this medium was considered to be both erosion and diffusion-mediated, in contrast to the release in 0, 10, 20, 40 and 50% ethanol media, where erosion-controlled release dominated. Image analysis of matrix swelling and swelling kinetics suggests a complex interaction between ethanol, hydrochlorothiazide and Carbopol 71 G accounting for the suppressed drug release in the ethanolic-media.
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How to cite this article:

M.O. Emeje, P.I. Nwabunike , C.Y. Isimi , O.O. Kunle and S.I. Ofoefule , 2008. Hydro-Alcoholic Media: An Emerging in vitro Tool for Predicting Dose Dumping from Controlled Release Matrices. Journal of Pharmacology and Toxicology, 3: 84-92.

DOI: 10.3923/jpt.2008.84.92

URL: https://scialert.net/abstract/?doi=jpt.2008.84.92

 
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