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Journal of Pharmacology and Toxicology

Year: 2008 | Volume: 3 | Issue: 6 | Page No.: 425-434
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Authors

Harshad C. Barbhaiya

Rajeshwari P. Desai

Vinod S. Saxena

K. Pravina

P. Wasim

P. Geetharani

J. Joshua Allan

K. Venkateshwarlu

A. Amit

Keywords

A randomized double blind placebo controlled study was designed to evaluate the efficacy and tolerability of BacoMind®, an enriched phytochemical composition from Bacopa monnieri on memory improvement upon chronic administration in elderly subjects as memory loss in elderly people is one of the leading health problems worldwide and its uncertain recovery with conventional therapies has paved way to elucidate the use of complementary and alternative system of medicine. Elderly individuals with mini mental state examination score of twenty four and above were enrolled. BacoMind® or placebo was given as a single oral dose of 450 mg daily for the duration of 12 weeks. The combination of well established battery of neuropsychological tests revealed that BacoMind® improved performance in tests associated with attention and verbal memory in elderly participants. Significant interaction effects between group and time were observed in digit span backward test (p = 0.008), list learning delayed recall test (p = 0.014), paired associates dissimilar delayed recall test (p = 0.047) and in visual retention-I test (p = 0.035). In conclusion, the study findings suggested that BacoMind® improved the cognitive functions such as attention and verbal memory in elderly individuals and was also found to be well tolerated.
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How to cite this article

Harshad C. Barbhaiya, Rajeshwari P. Desai, Vinod S. Saxena, K. Pravina, P. Wasim, P. Geetharani, J. Joshua Allan, K. Venkateshwarlu and A. Amit, 2008. Efficacy and Tolerability of BacoMind®on Memory Improvement in Elderly Participants - A Double Blind Placebo Controlled Study. Journal of Pharmacology and Toxicology, 3: 425-434.

DOI: 10.3923/jpt.2008.425.434

URL: https://scialert.net/abstract/?doi=jpt.2008.425.434

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