Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
Journal of Pharmacology and Toxicology
  Year: 2008 | Volume: 3 | Issue: 4 | Page No.: 272-278
DOI: 10.3923/jpt.2008.272.278
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail
Protective Effect of Raphanus sativus Against Carbon Tetrachloride Induced Hepatotoxicity In Wistar Albino Rats
N.H.SH. Mohammed, Afaf. I. Abelgasim and A.H. Mohammed

Abstract:
The present study aimed to investigate for a possible hepatoprotective activity of Raphanus sativus against carbon tetrachloride induced hepatotoxicity beside its toxicity and phytochemistry of the plant. Thirty albino rats were divided into 6 groups. The first served as a control, the second was injected with CCl4 and the four other groups were injected with CCl4 and treated orally and simultaneously with either methanolic or water extract at doses of 200 and 400 mg kg-1 (b.wt.). The animals were scarified after 10 days. The same doses were tested for toxicity. The phytochemical tests revealed presence of triterpenes, alkaloids, flavanoids, tannins, saponin and coumarins but negative for cyanogenic glycosides and anthraquinone glycosides. Biochemical results showed that CCl4 induced hepatotoxicity which was reduced by the use of the plant as indicated by inhibition of the increased serum AST, ALT and ALP activities and bilirubin concentration beside histopathological changes. Toxicity study indicated that Raphanus sativus had no adverse effect on livers.
PDF Fulltext XML References Citation Report Citation
How to cite this article:

N.H.SH. Mohammed, Afaf. I. Abelgasim and A.H. Mohammed , 2008. Protective Effect of Raphanus sativus Against Carbon Tetrachloride Induced Hepatotoxicity In Wistar Albino Rats. Journal of Pharmacology and Toxicology, 3: 272-278.

DOI: 10.3923/jpt.2008.272.278

URL: https://scialert.net/abstract/?doi=jpt.2008.272.278

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 

       

       

Curve Bottom