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Journal of Pharmacology and Toxicology
  Year: 2007 | Volume: 2 | Issue: 8 | Page No.: 748-752
DOI: 10.3923/jpt.2007.748.752
 
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Molecular Modelling Analysis of the Metabolism of Clotrimazole

Fazlul Huq

Abstract:
Clotrimazole (CTZ; bispheny l (2-chlorophenyl)-methan)) is an N-substituted imidazole drug that is used therapeutically as a topical antifungal agent. Molecular modelling analyses based on molecular mechanics, semi-empirical (PM3) and DFT (at B3LYP/6-31G* level) calculations show that both CTZ and its major metabolite 2-chlorophenybiphenylmethanol (2CLBPM) have LUMO-HOMO energy differences so that they would be kinetically inert. The molecular surface CTZ is found to abound in electron-deficient regions so that it can react with cellular nucleophiles such as glutathione and nucleobases in DNA thus causing depletion of glutathione and oxidation of nucleobases. The former would induce cellular toxicity due to oxidative stress and the latter would cause DNA damage. However, because of kinetic inertness of CTZ, the rates of such adverse reaction are expected to be low unless speeded up enzymatically.
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How to cite this article:

Fazlul Huq , 2007. Molecular Modelling Analysis of the Metabolism of Clotrimazole. Journal of Pharmacology and Toxicology, 2: 748-752.

DOI: 10.3923/jpt.2007.748.752

URL: https://scialert.net/abstract/?doi=jpt.2007.748.752

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