Research Article

**Hepatoprotective Effect of Methanolic Leaves Extracts of Tylophora asthmatica Against Paracetamol-Induced Liver Damage in Rats**

The aim of the present study was to evaluate the hepatoprotective and antioxidant properties of methanolic leaves extracts of Tylophora asthmatica (META) on paracetamol-induced (1 g kg^-1 body weight, i.p.,) hepatotoxicity in wistar strain of rats. The extract produced significant hepatoprotective effects as evidenced by decreased (p< 0.05) serum enzyme activities, ALT, AST, ALP, LDH and serum bilirubin (200 mg kg^-1 body weight orally for 21 days) compared with control group. For antioxidant activity, META exhibited significant (p< 0.05) hepatoprotective effect by increasing the levels of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and reducing lipid peroxidation (LPO). These results suggest that META may have hepatoprotective potential, probably by its antioxidant properties on hepatocytes and also support the use of the plant as a hepatoprotective agent.

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R. Malathi and M. Patrick Gomez, 2007. Hepatoprotective Effect of Methanolic Leaves Extracts of Tylophora asthmatica Against Paracetamol-Induced Liver Damage in Rats. Journal of Pharmacology and Toxicology, 2: 737-742.

DOI: 10.3923/jpt.2007.737.742

URL: https://scialert.net/abstract/?doi=jpt.2007.737.742

Journal of Pharmacology and Toxicology

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Authors

R. Malathi

M. Patrick Gomez

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Research Article

**Hepatoprotective Effect of Methanolic Leaves Extracts of Tylophora asthmatica Against Paracetamol-Induced Liver Damage in Rats**

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