Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
Journal of Pharmacology and Toxicology
  Year: 2007 | Volume: 2 | Issue: 8 | Page No.: 737-742
DOI: 10.3923/jpt.2007.737.742
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Hepatoprotective Effect of Methanolic Leaves Extracts of Tylophora asthmatica Against Paracetamol-Induced Liver Damage in Rats

R. Malathi and M. Patrick Gomez

Abstract:
The aim of the present study was to evaluate the hepatoprotective and antioxidant properties of methanolic leaves extracts of Tylophora asthmatica (META) on paracetamol-induced (1 g kg-1 body weight, i.p.,) hepatotoxicity in wistar strain of rats. The extract produced significant hepatoprotective effects as evidenced by decreased (p< 0.05) serum enzyme activities, ALT, AST, ALP, LDH and serum bilirubin (200 mg kg-1 body weight orally for 21 days) compared with control group. For antioxidant activity, META exhibited significant (p< 0.05) hepatoprotective effect by increasing the levels of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and reducing lipid peroxidation (LPO). These results suggest that META may have hepatoprotective potential, probably by its antioxidant properties on hepatocytes and also support the use of the plant as a hepatoprotective agent.
PDF Fulltext XML References Citation Report Citation
How to cite this article:

R. Malathi and M. Patrick Gomez , 2007. Hepatoprotective Effect of Methanolic Leaves Extracts of Tylophora asthmatica Against Paracetamol-Induced Liver Damage in Rats. Journal of Pharmacology and Toxicology, 2: 737-742.

DOI: 10.3923/jpt.2007.737.742

URL: https://scialert.net/abstract/?doi=jpt.2007.737.742

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 

Curve Bottom