Research Article

Therapeutic Effect of Indian Ayurvedic Herbal Formulation Triphala on Acetaminophen-Induced Hepatotoxicity in Mice

Mahaboob Khan Rasool, Evan Prince Sabina, Kumar Lavanya and Pichandi Nithya

Triphala, an Indian ayurvedic formulation used widely in ayurveda, is believed to promote health, immunity and longevity. The present study evaluates its hepatoprotective role. Triphala extract (100 mg kg^-1 b.wt.^-1, i.p.) inhibited acetaminophen (900 mg kg^-1 b.wt.^-1, i.p.) -induced hepatotoxicity in mice as indicated by the decrease of serum aminotransferases, alkaline phosphatase, inflammatory mediator TNF- α and hepatic lipid peroxidation. Triphala extract also protected acetaminophen-induced hepatic enzymic anti-oxidants and glutathione depletion. These observations demonstrate that Triphala treatment may attenuate acetaminophen-induced hepatoxicity in mice.

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Mahaboob Khan Rasool, Evan Prince Sabina, Kumar Lavanya and Pichandi Nithya, 2007. Therapeutic Effect of Indian Ayurvedic Herbal Formulation Triphala on Acetaminophen-Induced Hepatotoxicity in Mice. Journal of Pharmacology and Toxicology, 2: 725-731.

DOI: 10.3923/jpt.2007.725.731

URL: https://scialert.net/abstract/?doi=jpt.2007.725.731

Journal of Pharmacology and Toxicology

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Authors

Mahaboob Khan Rasool

Evan Prince Sabina

Kumar Lavanya

Pichandi Nithya

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Research Article

Therapeutic Effect of Indian Ayurvedic Herbal Formulation Triphala on Acetaminophen-Induced Hepatotoxicity in Mice

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