Research Article

Effects of Various Levels of Dietary Potassium Bromate on Wistar Rats

E.H. Abdel Gadir, W.S. Abdel Gadir and S.E.I. Adam

The toxicity to male Wistar rats of potassium bromate (KBrO₃) was investigated. KBrO₃was fed to rats at 75, 150, 600 and 1200 mg kg^-1 diet for 4 weeks. The rats fed diets containing 600 and 1200 mg kg^-1 of KBrO₃had the lowest growth rate but none of the rats died during the 4 week period. Depression in growth, nephropathy, hepatopathy and lymphocytic infiltration in vital organs were accompanied by anemia, leukopenia and alterations in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities with changes in concentration of urea, cholesterol and other serum constituents. Diet consisting of 150 mg kg^-1 of KBrO₃ was less toxic to rats.

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E.H. Abdel Gadir, W.S. Abdel Gadir and S.E.I. Adam, 2007. Effects of Various Levels of Dietary Potassium Bromate on Wistar Rats. Journal of Pharmacology and Toxicology, 2: 672-676.

DOI: 10.3923/jpt.2007.672.676

URL: https://scialert.net/abstract/?doi=jpt.2007.672.676

Journal of Pharmacology and Toxicology

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Authors

E.H. Abdel Gadir

W.S. Abdel Gadir

S.E.I. Adam

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Research Article

Effects of Various Levels of Dietary Potassium Bromate on Wistar Rats

How to cite this article

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