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Journal of Pharmacology and Toxicology

Year: 2007 | Volume: 2 | Issue: 7 | Page No.: 660-665
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Authors

K.S. Vidyalakshmi

A.I. Charles Dorni

Hannah R. Vasanthi

Keywords

Mussaenda queensirkit (MQ), an ornamental plant grown in tropical countries is shown to exhibit cytotoxic property. The 70% methanolic extract of fresh flowers of Mussaenda queensirkit (MQF) was studied for its cytotoxic and anti-mitotic activity with Brine Shrimp Lethality assay and Allium cepa Root Tip mitosis experiment, respectively. The LC50 value for MQF was found to be 83.33 μg mL-1 in Brine Shrimp Lethality Assay. The extract showed maximum anti-mitotic activity at the highest concentration studied (2000 μg mL-1) with a mitotic index of 9.0. In the MTT Assay for cytotoxic activity, MQF at 500 μg mL-1, showed a maximum of 71.44% inhibition against fibroblast cultured from skin compared to control whereas the standard, quercetin (50 μg mL-1) exhibited a maximum of 92.7% inhibition. The HPLC profile obtained had characteristic peaks due to flavonol glycosides which might be responsible for the observed cytotoxic and anti-mitotic activity of MQF. The observed cytotoxic and anti-mitotic activity of the extract shows the potential of the plant in the exploration of anti-cancer molecules.
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