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Journal of Pharmacology and Toxicology

Year: 2007 | Volume: 2 | Issue: 7 | Page No.: 646-652
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Authors

Patricia I. Franklin-Ude

Martins O. Emeje

Sabinus I. Ofoefule

Keywords

Research Article

Evaluation of Gellan Gum as a Mini-Matrix for Sustained Release of Ephedrine Hydrochloride Granules

Patricia I. Franklin-Ude, Martins O. Emeje and Sabinus I. Ofoefule
Gellan gum was evaluated for its swelling capacity and sustained release properties in varying pH media; 0.1 N hydrochloric acid (pH 1.2), simulated gastric juice (pH 1.5) and simulated intestinal fluid (pH 7.5). Granules were prepared by the conventional wet granulation method of massing and screening. Results obtained showed that the time for 50 (t50%) and 70% drug release (t70%) were higher for gellan gum than sodium carboxymethylcellulose. In vitro sustained release of ephedrine hydrochloride from granules in hard gelatin capsules was achieved over eight hours in all dissolution media. The matrix forming capacity of the polymer was concentration dependent and comparable to that of sodium carboxymethylcellulose. Maximum sustaining effect of gellan gum was achieved in the acidic media. The release kinetics of ephedrine hydrochloride from granules containing gellan gum was generally a mixture of first order and fickian diffusion. Gellan gum is suitable for the sustained-release formulation of ephedrine granules without the additional step of tablet formation.
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