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Journal of Pharmacology and Toxicology

Year: 2007 | Volume: 2 | Issue: 7 | Page No.: 630-637
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Authors

Paul A. Nwafor

F.K. Okwuasaba

Keywords

Research Article

Inhibitory Effect of Methanolic Extract of Asparagus pubescens Bak Root in Rats and Guinea Pigs Uterine Muscle

Paul A. Nwafor and F.K. Okwuasaba
The inhibitory effect of methanolic extract of Asparagus pubescens Bak root was studied in rat and guinea pig uterine muscles, respectively. The extract caused a concentration dependent decrease in frequency and amplitude of spontaneous activity in rat uterine muscle. It also caused a significant (p< 0.05-0.001) dose-dependent decrease in acetylcholine-induced contraction in guinea pig uterine muscle. The sensitization of the tissue caused by 8.0x10-6 g mL-1 of extract accentuated with 1.6x10-5 g mL-1 was blocked by verapamil, an extracellular calcium antagonist. The extract dose-dependently also inhibited Ach-induced contraction in Ca2+ free Physiological Salt Solution (PSS). This inhibition which was statistically significant (p< 0.05-0.001) was substantially reversed by addition of extracellular calcium. This inhibitory effect may in part involve the interference with intracellular/extracellular calcium mobilization.
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