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Journal of Pharmacology and Toxicology

Year: 2007 | Volume: 2 | Issue: 7 | Page No.: 621-629
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Authors

M. Sridevi

S. Senthil

K.V. Pugalendi

Keywords

Research Article

Antihyperglycemic Effect of Solanum surattense Leaf-Extract in Streptozotocin Induced Diabetic Rats

M. Sridevi, S. Senthil and K.V. Pugalendi
In the present study, we have evaluated the validity of traditional usage of Solanum surattense as an antidiabetic agent. Adult male albino rats of Wistar strain, weighing 180-200 g, were made diabetic by administration of streptozotocin (STZ) (40 mg kg-1 body weight) intraperitoneally. In a dose determination study, alcoholic leaf extract of S. surattense at 100, 200 and 300 mg kg-1 body weight was orally administrated for 15 days and the extract at 100 mg dose significantly reduced blood glucose and also found to reduce the increased lipid peroxidation marker in diabetic rats. Extending oral administration of 100 mg kg-1 bw to diabetic rats, for 45 days, resulted in a significant decrease in blood glucose and an increase in plasma insulin level. In addition, diabetic rats showed significant reduction in the glycogen content and in the activities of glucose metabolizing enzymes such as glucokinase, glucose 6-phosphate dehydrogenase and an elevation in the activities of gluconeogeneic enzymes such as glucose-6-phosphatase and fructose-1, 6-bisphosphatase. S. surattense extract administration to diabetic rats reversed these changes in a significant manner. Thus, the results show that S. surattense possesses antihyperglycemic activity and provide evidence for its traditional usage in the control of diabetes.
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