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Journal of Pharmacology and Toxicology
  Year: 2007 | Volume: 2 | Issue: 6 | Page No.: 551-558
DOI: 10.3923/jpt.2007.551.558
Effects of Losartan Potassium on Central Dopaminergic System in Mice
Vijay Pandi, Anantha Naik Nagappa and Prasad A. Thakurdesai

Abstract:
The present study was designed to evaluate the effect of Losartan Potassium (LP) pretreatment at various time intervals against apomorphine (APM) induced stereotyped behavior and haloperidol (HP) induced catalepsy in mice. LP (100 mg kg-1, p.o.) reduced the intensity of the APM induced stereotyped behavior at when administrated 3 h and 6 h. prior to APM. However, such reversal was not observed when LP pretreatment time was 1, 12 or 24 h. LP (100 mg kg-1) was also found to potentiate HP-induced catalepsy both pretreated (2 h prior) and co-administrated with LP. However, onset of catalepsy in co-administrated LP group was 240 min which as drastically different when LP was administrated 2 h prior to HP (30 min). These results suggests that effects of LP induced modulation of dopaminergic functions are not because of LP per se (t1/2 = 2.12 h) but because of its active metabolite, EXP 3174 (t1/2 = 6-9 h).
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How to cite this article:

Vijay Pandi, Anantha Naik Nagappa and Prasad A. Thakurdesai , 2007. Effects of Losartan Potassium on Central Dopaminergic System in Mice. Journal of Pharmacology and Toxicology, 2: 551-558.

DOI: 10.3923/jpt.2007.551.558

URL: https://scialert.net/abstract/?doi=jpt.2007.551.558

 
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