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Journal of Pharmacology and Toxicology
  Year: 2007 | Volume: 2 | Issue: 6 | Page No.: 542-550
DOI: 10.3923/jpt.2007.542.550
 
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Analgesic and Anti-inflammatory Effects of the Leaf Extracts of Pseudocedrella kotschyii Harms (Meliaceae)

Y.M. Musa, A.K. Haruna , M. Ilyas , A.H. Yaro , A.A. Ahmadu and H. Usman

Abstract:
The n-butanol soluble portion of the ethanolic extract of the leaves of Pseudocedrella kotschyii Harms, was evaluated for anti-nociceptive and anti-inflammatory activities in mice and rats, respectively. The n-butanol portion of the ethanolic extract (50 and 100 mg kg-1 body weight i.p.) exhibited a significant analgesic (acetic acid-induced writhes) and anti-inflammatory (raw egg albumin and formalin induced-oedema) effects. The analgesic and anti-inflammatory effects of the n-butanol portion of the ethanolic extract was comparable to piroxicam (20 mg kg-1 body weight i.p.), an analgesic and non-steroidal anti-inflammatory drug. The extract had an intraperitoneal LD50 of 1131 mg kg-1 body weight in mice. Preliminary phytochemical screening of the extract revealed the presence of carbohydrates, glycosides, steroids, tannins, saponins, flavonoids and terpenoids Present results make the n-butanol portion of the ethanol extract worthy of further investigation.
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How to cite this article:

Y.M. Musa, A.K. Haruna , M. Ilyas , A.H. Yaro , A.A. Ahmadu and H. Usman , 2007. Analgesic and Anti-inflammatory Effects of the Leaf Extracts of Pseudocedrella kotschyii Harms (Meliaceae). Journal of Pharmacology and Toxicology, 2: 542-550.

DOI: 10.3923/jpt.2007.542.550

URL: https://scialert.net/abstract/?doi=jpt.2007.542.550

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