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Journal of Pharmacology and Toxicology
  Year: 2007 | Volume: 2 | Issue: 6 | Page No.: 533-541
DOI: 10.3923/jpt.2007.533.541
Effect of Ramipril, Valsartan and Candesartan on Thermal and Visceral Pain in Mice
Omar M.E. Abdel Salam, Siham El-Shenawy and Salwa M. Nofal

Abstract:
The effect of the angiotensin converting enzyme inhibitor ramipril and the angiotensin II receptor blockers valsartan and candesartan on thermal and visceral pain was studied using the hot plate and abdominal stretching assays in mice. In both tests, ramipril (0.22 and 0.44 mg kg-1, s.c.) and valsartan (6.9 and 13.8 mg kg-1, s.c.), but not candesartan (0.69 and 1.38 mg kg-1, s.c.) produced a dose-related reduction in nociceptive responses. The analgesic effect of ramipril (0.22 mg kg-1, s.c.) in the writhing test was slightly reduced by co-treatment with atropine (1 mg kg-1, s.c.), but almost reversed by propranolol (1 mg kg-1, s.c.) or naloxone (5 mg kg-1, i.p.). Meanwhile, the analgesic effect of valsartan (13.8 mg kg-1, s.c.) was reversed by co-treatment with propranolol or atropine. These results suggest the involvement of beta adrenoceptor mediated mechanism in the visceral analgesic effect of ramipril and valsartan. In addition, results suggest that the visceral antinociceptive effect of ramipril is likely to involve an opioid sensitive mechanism; whilst that of valsartan involves a muscarinic acetylcholine receptor mediated mechanism.
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How to cite this article:

Omar M.E. Abdel Salam, Siham El-Shenawy and Salwa M. Nofal , 2007. Effect of Ramipril, Valsartan and Candesartan on Thermal and Visceral Pain in Mice. Journal of Pharmacology and Toxicology, 2: 533-541.

DOI: 10.3923/jpt.2007.533.541

URL: https://scialert.net/abstract/?doi=jpt.2007.533.541

 
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