Hypoglycemic, Hypolipidemic, Antioxidant and Male Sexual Improvement Potentials of Olive Oil in Alloxan Treated Rats

Research Article

Hypoglycemic, Hypolipidemic, Antioxidant and Male Sexual Improvement Potentials of Olive Oil in Alloxan Treated Rats

Diabetes mellitus is a degenerative disease that has deleterious effects on male reproductive function, possibly through an increase in oxidative stress by free radicals. The protection against such deleterious effects can be offerd by antioxidant supplementation. This study aimed to evaluate the significance of treatment of diabetic rats with olive oil in reducing oxidative stress, hyperglycemia, hyperlipidemia and testicular dysfunction induced by alloxan. The diabetic rats exhibited an increase in blood glucose, cholesterol, hydroperoxide levels and sperm abnormalities. Moreover, a significant decrease in the weights of sex organs, plasma testosterone, LH, sperm motility and sperm count was noticed in diabetic animals. Administration of olive oil to diabetic rats exhibited hypoglycemic and hypocholesterolemic effects associated with an improvement of sexual organ weights, hormone levels, sperm quality and sperm count. Furthermore, olive oil reduced the elevation of hydroperoxide level induced by alloxan. Administration of olive oil to normal rats showed hypocholesterolemic effect, a decrease in hydroperoxide level and increase in plasma testosterone level after eight weeks. On the other hand, olive oil has no significant influence on blood glucose, luteinizing hormone (LH) level, weight of sex organs, sperm quality and sperm count of normal rats. These results demonstrate that olive oil may be of advantage in lowering hyperglycemia, hypercholesterolemia, oxidative stress and deleterious effects on male reproductive functions induced by diabetes. It is suggested that the administration of olive oil may be helpful in alleviation of diabetic complications associated with oxidative stress and male reproductive dysfunction.

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I.M. Alhazza and Samir A.E. Bashandy, 2007. Hypoglycemic, Hypolipidemic, Antioxidant and Male Sexual Improvement Potentials of Olive Oil in Alloxan Treated Rats. Journal of Pharmacology and Toxicology, 2: 427-436.

DOI: 10.3923/jpt.2007.427.436

URL: https://scialert.net/abstract/?doi=jpt.2007.427.436

Journal of Pharmacology and Toxicology

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Authors

I.M. Alhazza

Samir A.E. Bashandy

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Research Article

Hypoglycemic, Hypolipidemic, Antioxidant and Male Sexual Improvement Potentials of Olive Oil in Alloxan Treated Rats

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